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Ernst-Friedrich-Pfeiffer Memorial Lecture. New aspects of C-peptide physiology

Wahren, J ; Johansson, B L

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1998, Vol.30 (1), p.A2-A5

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  • Título:
    Ernst-Friedrich-Pfeiffer Memorial Lecture. New aspects of C-peptide physiology
  • Autor: Wahren, J ; Johansson, B L
  • É parte de: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1998, Vol.30 (1), p.A2-A5
  • Notas: SourceType-Other Sources-1
    ObjectType-Speech/Lecture-1
    content type line 43
  • Descrição: C-peptide is co-secreted with insulin and has generally been considered not to possess biological activity. However, several recent studies during the last five years have demonstrated that administration of C-peptide in physiological amounts to type 1 diabetes (IDDM) patients on a short term basis (1-3h) results in decreased glomerular hyperfiltration, augmented glucose utilization and improved autonomic nerve function. More prolonged administration (1-3 months) of C-peptide to IDDM patients is accompanied by improvements in both renal function (diminished microalbuminuria) and autonomic and sensory nerve function. Both in vitro and in vivo data indicate that C-peptide may have a role in the regulation of insulin secretion. C-peptide's mechanism of action is not known but it may be related to its ability to stimulate Na+, K(+)-ATPase, activity, probably by activating a receptor coupled to a pertussis toxin-sensitive G-protein with subsequent activation of Ca2(+)-dependent intracellular signaling pathways. In conclusion, the combined findings indicate that C-peptide is a biologically active hormone. The possibility that C-peptide therapy in IDDM patients may be beneficial should be considered.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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