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Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Kiba, Wakako ; Imazato, Satoshi ; Takahashi, Yusuke ; Yoshioka, Seisuke ; Ebisu, Sigeyuki ; Nakano, Takayoshi

Journal of dentistry, 2010-10, Vol.38 (10), p.828-837 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Efficacy of polyphasic calcium phosphates as a direct pulp capping material
Autor: Kiba, Wakako ; Imazato, Satoshi ; Takahashi, Yusuke ; Yoshioka, Seisuke ; Ebisu, Sigeyuki ; Nakano, Takayoshi
Assuntos: Acid Etching, Dental - methods ; Acids ; Adhesives ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - therapeutic use ; Biological and medical sciences ; Bisphenol A-Glycidyl Methacrylate - chemistry ; Bond strength ; Ca release ; Calcium ; Calcium - chemistry ; Calcium phosphates ; Calcium Phosphates - chemistry ; Calcium Phosphates - therapeutic use ; Dental Bonding ; Dental Pulp Exposure - therapy ; Dentin ; Dentin bridge ; Dentin, Secondary - drug effects ; Dentin, Secondary - pathology ; Dentin-Bonding Agents - chemistry ; Dentistry ; Diffusion ; Direct pulp capping ; Durapatite - chemistry ; Durapatite - therapeutic use ; Etching ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Materials Testing ; Maxillofacial surgery. Dental surgery. Orthodontics ; Medical sciences ; Microscopy, Electron, Scanning ; Odontoblasts ; Physical properties ; Pulp Capping and Pulpectomy Agents - chemistry ; Pulp Capping and Pulpectomy Agents - therapeutic use ; Pulpitis - classification ; Rat ; Rats ; Rats, Wistar ; Regeneration - drug effects ; Resin Cements - chemistry ; Rodents ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Treatment Outcome ; X-Ray Diffraction
É parte de: Journal of dentistry, 2010-10, Vol.38 (10), p.828-837
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Abstract Objectives Polyphasic calcium phosphates (Poly-CaP), a complex of hydroxyapatite (HAp) and soluble calcium phosphates including α-tricalcium phosphate and tetracalcium phosphate, demonstrate promoting effects on hard tissue formation by osteoblasts. We hypothesized that a Poly-CaP block with a soluble calcium phosphates phase on one side and an insoluble HAp phase on the other side is useful for vital pulp therapy as it may promote dentin regeneration and provide the surface effective to achieve sealing. The purpose of this study was to investigate the efficacy of Poly-CaP as a direct pulp capping material by examining the Ca-release profile, the in vivo ability to induce reparative dentinogenesis, and the bonding of HAp surface with adhesive systems. Methods Poly-CaP prepared by annealing crude HAp disc was immersed in buffer solution at pH 7.4 or 4.0, and the concentration of Ca released was measured until 15 days. The pulp of 9-week-old Wister rat molar was exposed and capped with Poly-CaP or HAp block, and dentin bridge formation and pulpal inflammation was evaluated histopathologically after 2 or 4 weeks. Etch & rinse or self-etching adhesive was bonded to HAp surface, and the interface was observed using SEM. Results Poly-CaP exhibited continuous release of Ca with significantly greater amount than HAp at both pH conditions ( P < 0.05, Student's t -test). Animal tests demonstrated formation of complete dentin bridge at higher rate for Poly-CaP compared with HAp after 4 weeks ( P < 0.05, Steel–Dwass test). Impregnation of resin into etched HAp surface, with production of intimate contact at the bonding interface, was seen for all adhesives. Conclusions Poly-CaP is a potentially useful material for direct pulp capping with the advantages to promote dentin bridge formation and to provide tight sealing by adhesives.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês;Persa

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Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Kiba, Wakako ; Imazato, Satoshi ; Takahashi, Yusuke ; Yoshioka, Seisuke ; Ebisu, Sigeyuki ; Nakano, Takayoshi

Kidlington: Elsevier Ltd

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