Idioma:

Short-term and long-term pathological effects of glyceryl trierucate and of increasing levels of dietary rapeseed oil in rats

Abdellatif, A.M.M ; Vles, R.O

Nutrition and metabolism (Basel), 1973, Vol.15 (4/5), p.219-2319

Switzerland: S. Karger

Texto completo disponível

Citações Citado por

Enviar para

Título:
Short-term and long-term pathological effects of glyceryl trierucate and of increasing levels of dietary rapeseed oil in rats
Autor: Abdellatif, A.M.M ; Vles, R.O
Assuntos: animal diseases ; animal health ; Animals ; Body Weight - drug effects ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Dietary Fats - analysis ; Dose-Response Relationship, Drug ; Fatty Acids - analysis ; Fatty Acids, Unsaturated - adverse effects ; Heart - drug effects ; Heart Diseases - etiology ; Kidney - drug effects ; Kidney Diseases - etiology ; Kidney Tubules - drug effects ; Lipidoses - etiology ; Male ; noninfectious diseases ; Oils - administration & dosage ; Oils - adverse effects ; Oils - analysis ; Organ Size ; Rats ; Seeds ; Structure-Activity Relationship ; Time Factors ; Triglycerides - adverse effects ; Triglycerides - analysis
É parte de: Nutrition and metabolism (Basel), 1973, Vol.15 (4/5), p.219-2319
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Diets containing rapeseed oil (RSO) or glyceryl trierucate (GTE), each supplying 25 cal% erucic acid, were compared for their effect on the cardiac morphology in male Wistar rats after 1 week, and on growth, pathology and heart and kidney weights after 24 weeks. Sunflowerseed oil (SSO) and a rapeseed oil supplying ca. 4 cal% erucic acid (LER) served as control fats. The RSO and GTE diets produced similar effects. After 1 week, cardiac lipidosis was observed in both dietary groups; after 24 weeks, lipidosis had decreased remarkably and cellular scars were the main pathological feature. The severity of the lipidosis and of the fibrotic changes was similar in both groups. Growth and the relative weights of the heart and kidneys were significantly different - mutually as well as in comparison with the control rats fed SSO. It was concluded that erucic acid is the main pathogenic fatty acid in RSO, but other long-chain fatty acids may also play a minor role. The animals fed LER showed normal growth and organ weights compared with the SSO group. Slight cardiac lipidosis was observed after 1 week. After 24 weeks, some animals showed cardiac cellular scars varying in intensity from slight to moderate. In a second experiment, Sprague-Dawley rats were fed 0, 5, 10, 15, 20, 25 or 30 cal% RSO in diets made isocaloric in fat by addition of SSO. The rats were killed after 3 and 6 days and 32 weeks. All rats fed RSO for 3 and 6 days showed a dose-related lipidosis of the heart. The groups fed RSO for 32 weeks showed myocardial changes which were already manifest in a few animals on the 5 cal% RSO diet. Incidence and severity of these changes increased according as the RSO content of the diet was increased.
Editor: Switzerland: S. Karger
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Short-term and long-term pathological effects of glyceryl trierucate and of increasing levels of dietary rapeseed oil in rats

Abdellatif, A.M.M ; Vles, R.O

Switzerland: S. Karger

Buscando em bases de dados remotas. Favor aguardar.