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Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis

Becker, Lara V. ; Rosa, Cintia S. ; Souza, Viviane do C.G. ; Bagatini, Margarete D. ; Casali, Emerson A. ; Leal, Claudio Alberto M. ; da Silva, João Carlos N. ; Moretto, Maria Beatriz ; Pinheiro, Francielle de V. ; Morsch, Vera Maria ; Schetinger, Maria Rosa C. ; Leal, Daniela B.R.

Clinical biochemistry, 2010-09, Vol.43 (13), p.1096-1100 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

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Título:
Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis
Autor: Becker, Lara V. ; Rosa, Cintia S. ; Souza, Viviane do C.G. ; Bagatini, Margarete D. ; Casali, Emerson A. ; Leal, Claudio Alberto M. ; da Silva, João Carlos N. ; Moretto, Maria Beatriz ; Pinheiro, Francielle de V. ; Morsch, Vera Maria ; Schetinger, Maria Rosa C. ; Leal, Daniela B.R.
Assuntos: 5'-Nucleotidase ; Adenine nucleotides ; Adenine Nucleotides - metabolism ; Adenosine ; Adenosine Deaminase ; Adult ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - enzymology ; Arthritis, Rheumatoid - metabolism ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - etiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Platelets - enzymology ; Blood Platelets - metabolism ; Cardiology. Vascular system ; Case-Control Studies ; Diseases of the osteoarticular system ; Female ; Humans ; Hydrolases - metabolism ; Hydrolysis ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Phosphoric Diester Hydrolases ; Platelets ; Pyrophosphatases ; Rheumatoid arthritis
É parte de: Clinical biochemistry, 2010-09, Vol.43 (13), p.1096-1100
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Descrição: To investigate whether there are changes in the activity of the enzymes NTPDase, 5′-nucleotidase, E-NPP and ADA in platelets from patients with rheumatoid arthritis (RA). Thirty-five RA patients diagnosed with RA through American College of Rheumatology criteria, as well as 35 healthy patients were selected. NTPDase, 5′-nucleotidase, E-NPP and ADA activities were verified in platelets isolated from these patients. The results demonstrate that an increase in NTPDase (approximately 100%), 5′-nucleotidase (170%), E-NPP (approximately 100%) and ADA (approximately 45%) activities occurred in RA patients when compared to the control group. Ours results suggest an increase in the NTPDase, 5′-nucleotidase and E-NPP activities, which could be related to a compensatory organic response to excessive platelet aggregation which occurs during the inflammation. The increased ADA activity found in this work could lead to a decrease in the adenosine concentration in the circulation, which could explain the accelerated atherosclerosis found in patients with RA.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

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Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis

Becker, Lara V. ; Rosa, Cintia S. ; Souza, Viviane do C.G. ; Bagatini, Margarete D. ; Casali, Emerson A. ; Leal, Claudio Alberto M. ; da Silva, João Carlos N. ; Moretto, Maria Beatriz ; Pinheiro, Francielle de V. ; Morsch, Vera Maria ; Schetinger, Maria Rosa C. ; Leal, Daniela B.R.

Amsterdam: Elsevier Inc

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