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Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains

Abreu, Renata Viana ; Silva-Oliveira, Eliane Moretto ; Moraes, Márcio Flávio Dutra ; Pereira, Grace Schenatto ; Moraes-Santos, Tasso

Pharmacology, biochemistry and behavior, 2011-10, Vol.99 (4), p.659-664 [Periódico revisado por pares]

Kidlington: Elsevier Inc

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Título:
Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains
Autor: Abreu, Renata Viana ; Silva-Oliveira, Eliane Moretto ; Moraes, Márcio Flávio Dutra ; Pereira, Grace Schenatto ; Moraes-Santos, Tasso
Assuntos: Animals ; Antioxidants - metabolism ; Biological and medical sciences ; Body Weight - drug effects ; Brain Chemistry - drug effects ; Caffeine ; Caffeine - pharmacology ; Coffee ; Cognition - drug effects ; Diet ; Eating - drug effects ; Endogenous antioxidant system ; Exploratory Behavior - drug effects ; Glutathione - metabolism ; Learning and memory ; Lipid Peroxidation - drug effects ; Male ; Medical sciences ; Motor Activity - drug effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - drug effects ; Psychopharmacology ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism
É parte de: Pharmacology, biochemistry and behavior, 2011-10, Vol.99 (4), p.659-664
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Descrição: Coffee is a popular beverage consumed worldwide and its effect on health protection has been well studied throughout literature. This study investigates the effect of chronic coffee and caffeine ingestion on cognitive behavior and the antioxidant system of rat brains. The paradigms of open field and object recognition were used to assess locomotor and exploratory activities, as well as learning and memory. The antioxidant system was evaluated by determining the activities of glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD), as well as the lipid peroxidation and reduced glutathione content. Five groups of male rats were fed for approximately 80days with different diets: control diet (CD), fed a control diet; 3% coffee diet (3%Co) and 6% coffee diet (6%Co), both fed a diet containing brewed coffee; 0.04% caffeine diet (0.04%Ca) and 0.08% caffeine diet (0.08%Ca), both fed a control diet supplemented with caffeine. The estimated caffeine intake was approximately 20 and 40mg/kg per day, for the 3%Co–0.04%Ca and 6%Co–0.08%Ca treatments, respectively. At 90days of life, the animals were subjected to the behavioral tasks and then sacrificed. The results indicated that the intake of coffee, similar to caffeine, improved long-term memory when tested with object recognition; however, this was not accompanied by an increase in locomotor and exploratory activities. In addition, chronic coffee and caffeine ingestion reduced the lipid peroxidation of brain membranes and increased the concentration of reduced-glutathione. The activities of the GR and SOD were similarly increased, but no change in GPx activity could be observed. Thus, besides improving cognitive function, our data show that chronic coffee consumption modulates the endogenous antioxidant system in the brain. Therefore, chronic coffee ingestion, through the protection of the antioxidant system, may play an important role in preventing age-associated decline in the cognitive function. ► Chronic coffee ingestion improves long-term memory of rats. ► Coffee does not alter the locomotion activity or the exploratory behavior. ► Coffee consumption modulates endogenous antioxidant system in rat brain. ► Coffee decreases the cognitive decline by protecting the brain oxidative system.
Editor: Kidlington: Elsevier Inc
Idioma: Inglês

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Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains

Abreu, Renata Viana ; Silva-Oliveira, Eliane Moretto ; Moraes, Márcio Flávio Dutra ; Pereira, Grace Schenatto ; Moraes-Santos, Tasso

Kidlington: Elsevier Inc

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