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Comparative Immunogenicity and Cross-Clade Protective Efficacy of Mammalian Cell-Grown Inactivated and Live Attenuated H5N1 Reassortant Vaccines in Ferrets

Gustin, Kortney M. ; Maines, Taronna R. ; Belser, Jessica A. ; van Hoeven, Neal ; Lu, Xuihua ; Dong, Libo ; Isakova-Sivak, Irina ; Chen, Li-Mei ; Voeten, J. Theo M. ; Heldens, Jacco G. M. ; van den Bosch, Han ; Cox, Nancy J. ; Tumpey, Terrence M. ; Klimov, Alexander I. ; Rudenko, Larisa ; Donis, Ruben O. ; Katz, Jacqueline M.

The Journal of infectious diseases, 2011-11, Vol.204 (10), p.1491-1499 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Comparative Immunogenicity and Cross-Clade Protective Efficacy of Mammalian Cell-Grown Inactivated and Live Attenuated H5N1 Reassortant Vaccines in Ferrets
Autor: Gustin, Kortney M. ; Maines, Taronna R. ; Belser, Jessica A. ; van Hoeven, Neal ; Lu, Xuihua ; Dong, Libo ; Isakova-Sivak, Irina ; Chen, Li-Mei ; Voeten, J. Theo M. ; Heldens, Jacco G. M. ; van den Bosch, Han ; Cox, Nancy J. ; Tumpey, Terrence M. ; Klimov, Alexander I. ; Rudenko, Larisa ; Donis, Ruben O. ; Katz, Jacqueline M.
Assuntos: Animals ; Antibodies ; Antibodies, Viral - analysis ; Cross Protection - immunology ; Dosage ; Ferrets ; H5N1 subtype influenza A virus ; Immune response ; Infections ; Influenza A virus ; Influenza A Virus, H5N1 Subtype - genetics ; Influenza A Virus, H5N1 Subtype - immunology ; Influenza vaccines ; Influenza Vaccines - immunology ; Male ; Mustela ; Pandemics ; Vaccination ; Vaccines, Attenuated - genetics ; Vaccines, Attenuated - immunology ; Vaccines, Inactivated - immunology ; Vaccines, Synthetic - immunology ; Virus Cultivation - methods ; Virus Shedding ; Viruses
É parte de: The Journal of infectious diseases, 2011-11, Vol.204 (10), p.1491-1499
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cross-dade protection against this rapidly evolving virus. We report a comparative evaluation in ferrets of the immunogenicity and cross-protective efficacy of isogenic mammalian cell-grown, live attenuated influenza vaccine (LAIV) and adjuvanted, whole-virus, inactivated influenza vaccine (IIV), produced from a clade 1 H5N1 6:2 reassortant vaccine candidate (caVN1203-Lenl7rg) based on the cold-adapted A/Leningrad/134/17/57 (H2N2) master donor virus. Two doses of LAIV or IIV provided complete protection against lethal homologous H5N1 virus challenge and a reduction in virus shedding and disease severity after heterologous clade 2.2.1 H5N1 virus challenge and increased virus-specific serum and nasal wash antibody levels. Although both vaccines demonstrated cross-protective efficacy, LAIV induced higher levels of nasal wash IgA and reduction of heterologous virus shedding, compared with IIV. Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-dade protection.
Editor: Oxford: Oxford University Press
Idioma: Inglês;Russo

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Comparative Immunogenicity and Cross-Clade Protective Efficacy of Mammalian Cell-Grown Inactivated and Live Attenuated H5N1 Reassortant Vaccines in Ferrets

Oxford: Oxford University Press

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