Idioma:

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

Wong, Alexander R. C. ; Pearson, Jaclyn S. ; Bright, Michael D. ; Munera, Diana ; Robinson, Keith S. ; Lee, Sau Fung ; Frankel, Gad ; Hartland, Elizabeth L.

Molecular microbiology, 2011-06, Vol.80 (6), p.1420-1438 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements
Autor: Wong, Alexander R. C. ; Pearson, Jaclyn S. ; Bright, Michael D. ; Munera, Diana ; Robinson, Keith S. ; Lee, Sau Fung ; Frankel, Gad ; Hartland, Elizabeth L.
Assuntos: Animals ; Bacteriology ; Biological and medical sciences ; Cells ; E coli ; Enterohemorrhagic Escherichia coli - genetics ; Enterohemorrhagic Escherichia coli - metabolism ; Enterohemorrhagic Escherichia coli - pathogenicity ; Enteropathogenic Escherichia coli - genetics ; Enteropathogenic Escherichia coli - metabolism ; Enteropathogenic Escherichia coli - pathogenicity ; Escherichia coli ; Escherichia coli Infections - metabolism ; Escherichia coli Infections - microbiology ; Escherichia coli Proteins - genetics ; Escherichia coli Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Microbiology ; Miscellaneous ; Pathogens ; Signal Transduction
É parte de: Molecular microbiology, 2011-06, Vol.80 (6), p.1420-1438
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Summary The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) share a unique mechanism of colonization that results from the concerted action of effector proteins translocated into the host cell by a type III secretion system (T3SS). EPEC and EHEC not only induce characteristic attaching and effacing (A/E) lesions, but also subvert multiple host cell signalling pathways during infection. Our understanding of the mechanisms by which A/E pathogens hijack host cell signalling has advanced dramatically in recent months with the identification of novel activities for many effectors. In addition to further characterization of established effectors (Tir, EspH and Map), new effectors have emerged as important mediators of virulence through activities such as mimicry of Rho guanine nucleotide exchange factors (Map and EspM), inhibition of apoptosis (NleH and NleD), interference with inflammatory signalling pathways (NleB, NleC, NleE and NleH) and phagocytosis (EspF, EspH and EspJ). The findings have highlighted the multifunctional nature of the effectors and their ability to participate in redundant, synergistic or antagonistic relationships, acting in a co‐ordinated spatial and temporal manner on different host organelles and cellular pathways during infection.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

Wong, Alexander R. C. ; Pearson, Jaclyn S. ; Bright, Michael D. ; Munera, Diana ; Robinson, Keith S. ; Lee, Sau Fung ; Frankel, Gad ; Hartland, Elizabeth L.

Oxford, UK: Blackwell Publishing Ltd

Buscando em bases de dados remotas. Favor aguardar.