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Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita

Nagalekshmi, R. ; Menon, Aditya ; Chandrasekharan, Dhanya K. ; Nair, Cherupally Krishnan Krishnan

Food and chemical toxicology, 2011-12, Vol.49 (12), p.3367-3373 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita
Autor: Nagalekshmi, R. ; Menon, Aditya ; Chandrasekharan, Dhanya K. ; Nair, Cherupally Krishnan Krishnan
Assuntos: Acanthaceae ; acetaminophen ; Acetaminophen - toxicity ; Administration, Oral ; alanine transaminase ; Alanine Transaminase - blood ; alkaline phosphatase ; Alkaline Phosphatase - blood ; Andrographis - chemistry ; Andrographis paniculata ; Animals ; Aspartate Aminotransferases - blood ; aspartate transaminase ; bilirubin ; Bilirubin - blood ; Biological and medical sciences ; Biomarkers - blood ; blood serum ; catalase ; Catalase - metabolism ; Chemical and Drug Induced Liver Injury - drug therapy ; dose response ; Female ; Gentianaceae ; glutathione ; Glutathione - metabolism ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Hepatoprotection ; hepatoprotective effect ; hepatotoxicity ; histopathology ; India ; Lipid Peroxides - blood ; liver ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Liver marker enzymes ; Medical sciences ; medicinal plants ; Mice ; oral administration ; Paracetamol ; peroxides ; plant extracts ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Swertia ; Swertia - chemistry ; Swertia chirayita ; Toxicology
É parte de: Food and chemical toxicology, 2011-12, Vol.49 (12), p.3367-3373
Notas: http://dx.doi.org/10.1016/j.fct.2011.09.026
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: ► Ethanolic extracts of A. paniculata and S. chirayita showed hepatoprotecting property. ► Various phytochemicals were found in both plants extracts. ► A. paniculata had 14 phytochemicals and S. chirayita had 10 phytochemicals, respectively, on HPTLC analysis. ► Two compounds were found identical in both extracts as confirmed by HPLC. Andrographis paniculata (Family: Acanthaceae) and Swertia chirayita (Family: Gentianaceae) are two controversial medicinal plants used as Kiriyattu, having similar therapeutic action and are used as a hepatoprotective and hepatostimulative agent. A. paniculata grows in southern parts of India and S. chirayita in the Himalayan region. The present work concerns on the ability of the extracts of these plants to offer protection against acute hepatotoxicity induced by paracetamol (150mg/kg) in Swiss albino mice. Oral administration of A. paniculata or S. chirayita extract (100–200mg/kg) offered a significant dose dependent protection against paracetamol induced hepatotoxicity as assessed in terms of biochemical and histopathological parameters. The paracetamol induced elevated levels of serum marker enzymes such as serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), and bilirubin in peripheral blood serum and distorted hepatic tissue architecture along with increased levels of lipid peroxides (LPO) and reduction of superoxide dismutase (SOD), catalase, reduced glutathione (GSH) and glutathione peroxidase (GPx) in liver tissue. Administration of the plant extracts after paracetamol insult restored the levels of these parameters to control (untreated) levels. Thus the present study revealed that the extracts of A. paniculata or S. chirayita offered protection against hepatotoxicity induced by paracetamol.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita

Nagalekshmi, R. ; Menon, Aditya ; Chandrasekharan, Dhanya K. ; Nair, Cherupally Krishnan Krishnan

Oxford: Elsevier Ltd

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