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Acid-base analysis during experimental anemia in rats

Pesquero, J ; Alfaro, V ; Palacios, L

Canadian journal of physiology and pharmacology, 2000-10, Vol.78 (10), p.774-780 [Periódico revisado por pares]

Ottawa, Canada: NRC Research Press

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Título:
Acid-base analysis during experimental anemia in rats
Autor: Pesquero, J ; Alfaro, V ; Palacios, L
Assuntos: Acid-Base Imbalance - blood ; Acids ; Alkalosis, Respiratory - blood ; Anemia - blood ; Anemia - chemically induced ; Anemias. Hemoglobinopathies ; Animals ; Bicarbonates - blood ; Biological and medical sciences ; Carbon Dioxide - blood ; Diseases of red blood cells ; Erythrocytes - metabolism ; Hematologic and hematopoietic diseases ; Hemorrhage - blood ; Hydrogen-Ion Concentration ; Hypocapnia - blood ; Male ; Medical sciences ; Phenylhydrazines ; Rats ; Rats, Sprague-Dawley ; Stewart, PA
É parte de: Canadian journal of physiology and pharmacology, 2000-10, Vol.78 (10), p.774-780
Descrição: The present study evaluated the acid-base status of anemic rats by using two approaches of acid-base analysis: one based on the base excess (BE) calculation and the other based on Stewart's physicochemical analysis. Two sets of experimental data, derived from two different methods of inducing anemia, were used: repetitive doses of phenylhydrazine (PHZ) and bleeding (BL). A significant uncompensated respiratory alkalosis was found in both groups of anemic rats. BE increased slightly, whereas strong ion difference ([SID]) and weak acid buffers ([A TOT ]) remained unchanged in anemic rats. The reasons for the absence of compensation for hypocapnia and the differences in the behaviour of acid-base variables are discussed. BE increase was considered paradoxical; its calculation was affected by the experimental conditions and BE had little physiological relevance during anemia. The absence of metabolic renal compensation in anemic rats could be due to a lower pH in the kidney due to anemic hypoxia. Finally, the changes in buffer strength related to low Hb and low Pc0 2 might influence plasma [SID] through counteracted shifts of strong ions between erythrocytes and plasma, finally resulting in unchanged [SID] during anemia.Key words: anemia, phenylhydrazine, bleeding, base excess, strong ion difference, non-carbonic buffers.
Editor: Ottawa, Canada: NRC Research Press
Idioma: Inglês

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Acid-base analysis during experimental anemia in rats

Pesquero, J ; Alfaro, V ; Palacios, L

Ottawa, Canada: NRC Research Press

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