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Influence of Dissolution Medium Agitation on Release Profiles of Sustained-Release Tablets

Costa, Paulo ; Lobo, J. M. Sousa

Drug development and industrial pharmacy, 2001-01, Vol.27 (8), p.811-817 [Periódico revisado por pares]

Colchester: Informa UK Ltd

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Título:
Influence of Dissolution Medium Agitation on Release Profiles of Sustained-Release Tablets
Autor: Costa, Paulo ; Lobo, J. M. Sousa
Assuntos: Algorithms ; Antianginal agents. Coronary vasodilator agents ; Antihypertensive agents ; Biological and medical sciences ; Calcium Channel Blockers - administration & dosage ; Calcium Channel Blockers - chemistry ; Cardiovascular system ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid ; Delayed-Action Preparations - chemistry ; Diltiazem - administration & dosage ; Diltiazem - chemistry ; Diltiazem hydrochloride ; Dissolution assay ; General pharmacology ; Hardness ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Sink conditions ; Solubility ; Solvents ; Tablets
É parte de: Drug development and industrial pharmacy, 2001-01, Vol.27 (8), p.811-817
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Reaching nearly perfect sink conditions is very important in the determination of drug dissolution rates. Many times, the only factor that is taken into consideration in achieving sink conditions is the relation between the drug concentration and its solubility. The analytical conditions of the dissolution assay, as well as the dissolution apparatus, stirring speed, and nature and volume of the dissolution fluid may also influence the dissolution results. The main objective of this work was to study the influence of the stirring rate conditions and of the dissolution apparatus in the diltiazem hydrochloride release from tablets. Diltiazem hydrochloride sustained-release (SR) tablets were tested and the following dissolution parameters were evaluated: t10%, t25%, t50%, dissolution time, mean dissolution time (MDT), and dissolution efficiency (DE) at t120, and at t360. To analyze the release mechanism, several release models were tested, such as Higuchi, zero order, first order, Baker-Lonsdale, Hixson-Crowell, Weibull, and Korsmeyer-Peppas. The similarities between two in vitro dissolution profiles were assessed by the similarity factor f2. The in vitro release kinetics of diltiazem hydrochloride sustained-release tablets were evaluated using the USP 2 (paddle) and USP 4 (flow-through) apparatus.
Editor: Colchester: Informa UK Ltd
Idioma: Inglês

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Influence of Dissolution Medium Agitation on Release Profiles of Sustained-Release Tablets

Costa, Paulo ; Lobo, J. M. Sousa

Colchester: Informa UK Ltd

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