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Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay

MACHADO, A ; EMODI, K ; BARRETO, F ; REIS, M. G ; ARRUDA, S ; RILEY, L. W ; TAKENAMI, I ; FINKMOORE, B. C ; BARBOSA, T ; CARVALHO, J ; CAVALCANTI, L ; SANTOS, G ; TAVARES, M ; MOTA, M

The international journal of tuberculosis and lung disease, 2009-04, Vol.13 (4), p.446-453 [Periódico revisado por pares]

Paris, France: IUATLD

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Título:
Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay
Autor: MACHADO, A ; EMODI, K ; BARRETO, F ; REIS, M. G ; ARRUDA, S ; RILEY, L. W ; TAKENAMI, I ; FINKMOORE, B. C ; BARBOSA, T ; CARVALHO, J ; CAVALCANTI, L ; SANTOS, G ; TAVARES, M ; MOTA, M
Assuntos: Adolescent ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Household Contacts ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Interferon-gamma - blood ; Interferon-Gamma Release Assay ; Latent Tuberculosis Infection ; Male ; Medical sciences ; Mycobacterium ; Pneumology ; Respiratory system : syndromes and miscellaneous diseases ; Tuberculin Skin Test ; Tuberculin Test ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - transmission
É parte de: The international journal of tuberculosis and lung disease, 2009-04, Vol.13 (4), p.446-453
Notas: (R) Medicine - General
1027-3719(20090401)13:4L.446;1-
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: OBJECTIVE: To analyze factors associated with discordance between tuberculin skin test (TST) and interferon-gamma release assay (IGRA) results among household contacts of pulmonary tuberculosis (PTB) patients.DESIGN: TST (purified protein derivative) and IGRA (QuantiFERON®-TB Gold) were performed on household contacts of PTB patients diagnosed between 2006 and 2007 in Salvador, Brazil. Discordant test groups were compared with the TST−/IGRA− group.RESULTS: Of 261 household contacts satisfactorily tested by TST, 145 (55.6%) had positive TST results; of 298 satisfactorily tested by IGRA, 127 (43.1%) had positive results. The test agreement was 0.76 (κ = 0.53, 95%CI 0.43-0.63). Sixty-one (24%) were discordant: 44 (72%) with TST+/IGRA− and 17 (28%) with TST−/IGRA+ results. Compared to the TST−/IGRA− group, the TST+/IGRA− and TST+/IGRA+ groups were significantly more likely to have a chest X-ray showing old lung scars (OR = 6.8, 95%CI 1.3-35.0; OR = 7.4, 95%CI 2.2-24.4, respectively). The TST−/IGRA+ group was exposed to their index cases for significantly longer than the TST−/IGRA− group (OR = 7.2, 95%CI 1.7-29.3).CONCLUSION: The TST+/IGRA− and TST+/IGRA+ groups shared more similar characteristics with each other than with the TST−/IGRA− group. In a setting endemic for TB, TST results appear to be more suitable in the decision to treat latent TB infection.
Editor: Paris, France: IUATLD
Idioma: Inglês

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Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay

MACHADO, A ; EMODI, K ; BARRETO, F ; REIS, M. G ; ARRUDA, S ; RILEY, L. W ; TAKENAMI, I ; FINKMOORE, B. C ; BARBOSA, T ; CARVALHO, J ; CAVALCANTI, L ; SANTOS, G ; TAVARES, M ; MOTA, M

Paris, France: IUATLD

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