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Bacteria and biofilm in respiratory tract infections
Drago, Lorenzo
Le infezioni in medicina, 2009-07, Vol.17 Suppl 2, p.3
[Periódico revisado por pares]
Italy
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Título:
Bacteria and biofilm in respiratory tract infections
Autor:
Drago, Lorenzo
Assuntos:
Anti-Bacterial Agents - therapeutic use
;
Biofilms
-
drug
effects
;
Dose-Response Relationship,
Drug
;
Drug
Resistance, Microbial
;
Drug
Resistance, Multiple, Bacterial
;
Haemophilus Infections -
drug
therapy
;
Haemophilus Infections - microbiology
;
Haemophilus influenzae -
drug
effects
;
Haemophilus influenzae - physiology
;
Humans
;
Microbial Sensitivity Tests
;
Pseudomonas aeruginosa -
drug
effects
;
Pseudomonas aeruginosa - physiology
;
Pseudomonas Infections -
drug
therapy
;
Pseudomonas Infections - microbiology
;
Respiratory Tract Infections - microbiology
;
Streptococcal Infections -
drug
therapy
;
Streptococcal Infections - microbiology
;
Streptococcus pneumoniae -
drug
effects
;
Streptococcus pneumoniae - physiology
É parte de:
Le infezioni in medicina, 2009-07, Vol.17 Suppl 2, p.3
Descrição:
Biofilm is a structured community of bacterial cells included in a self-produced polymeric matrix adherent to an inert or living surface. The main property of biofilm consists of making microrganisms more resistant to exogenous insults. Antibiotic therapy typically resolves symptoms determined by planktonic cells released by biofilms but is not able to eradicate and completely clear biofilm. This is why infections sustained by biofilm-producer bacteria are often recurrent, making mandatory repeated antibiotic treatments. The typical conformation of biofilm, the phenotypical and genetical features existing among the different microrganisms confer a natural resistance to a number of antimicrobials so that it is necessary to test antimicrobial activity against the microbial species itself and also against biofilm, when it is present. Comparative studies, performed on quinolones and beta-lactams, evidenced a significant activity against biofilm produced by pneumococci, haemophyli and pseudomonas as well.
Editor:
Italy
Idioma:
Italiano
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