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Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Fraga, Vanessa G ; Guimarães, Henrique C ; Teixeira, Antônio L ; Barbosa, Maira T ; Mateo, Elvis C C ; Carvalho, Maria G ; Caramelli, Paulo ; Gomes, Karina B

Arquivos de neuro-psiquiatria, 2015-11, Vol.73 (11), p.899 [Periódico revisado por pares]

Brazil

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Título:
Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia
Autor: Fraga, Vanessa G ; Guimarães, Henrique C ; Teixeira, Antônio L ; Barbosa, Maira T ; Mateo, Elvis C C ; Carvalho, Maria G ; Caramelli, Paulo ; Gomes, Karina B
Assuntos: Age Factors ; Aged ; Cognition Disorders - genetics ; Cognition Disorders - metabolism ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotyping Techniques ; Humans ; Interleukin-6 - biosynthesis ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Male ; Neuropsychological Tests ; Polymorphism, Single Nucleotide ; Prospective Studies ; Risk Factors ; Severity of Illness Index
É parte de: Arquivos de neuro-psiquiatria, 2015-11, Vol.73 (11), p.899
Descrição: Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up.Methods The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups.Results We observed that individuals with cognitive impairment no dementia with GGlowergenotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigherallele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95%= 1.087-8.812).Conclusion These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.
Editor: Brazil
Idioma: Inglês

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Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Fraga, Vanessa G ; Guimarães, Henrique C ; Teixeira, Antônio L ; Barbosa, Maira T ; Mateo, Elvis C C ; Carvalho, Maria G ; Caramelli, Paulo ; Gomes, Karina B

Brazil

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