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Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment

Xiong, Z Q ; Tang, X C ; Lin, J L ; Zhu, D Y

Zhōngguó yàoli xuébào, 1995, Vol.16 (1), p.21-25 [Periódico revisado por pares]

Beijing: Science Press

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Título:
Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment
Autor: Xiong, Z Q ; Tang, X C ; Lin, J L ; Zhu, D Y
Assuntos: Acetylcholinesterase - metabolism ; Animals ; Biological and medical sciences ; Cholinesterase Inhibitors - pharmacology ; Cholinesterase Inhibitors - therapeutic use ; Erythrocyte Membrane - enzymology ; Male ; Medical sciences ; Memory Disorders - chemically induced ; Memory Disorders - drug therapy ; Miscellaneous ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Scopolamine Hydrobromide ; Sesquiterpenes - pharmacology ; Sesquiterpenes - therapeutic use
É parte de: Zhōngguó yàoli xuébào, 1995, Vol.16 (1), p.21-25
Descrição: To study the effects of isovanihuperzine A (IVHA) on cholinesterase and scopolamine-induced memory deficit. AChE and BuChE activities were determined by the colorimetric method of Ellman. The Ki value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, rats were trained to perform a radial arm maze task using a partially baited procedure. The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A), and was more potent than those of physostigmine and galanthamine with an IC50 value of 0.11 mumol.L-1. IVHA was a mixed competitive type with a Ki value of 32 nmol.L-1. It bound to AChE in a reversible manner. IVHA at a dose of 0.2 mg.kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze. IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer.
Editor: Beijing: Science Press
Idioma: Inglês

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Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment

Xiong, Z Q ; Tang, X C ; Lin, J L ; Zhu, D Y

Beijing: Science Press

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