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Experimental models in research of the pathomechanism of diabetes mellitus

Pusztai, P ; Prechl, J ; Somogyi, A ; Szaleczky, E ; Fehér, J

Orvosi hetilap, 1996-08, Vol.137 (34), p.1865 [Periódico revisado por pares]

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Título:
Experimental models in research of the pathomechanism of diabetes mellitus
Autor: Pusztai, P ; Prechl, J ; Somogyi, A ; Szaleczky, E ; Fehér, J
Assuntos: Alloxan - pharmacology ; Animals ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 1 - chemically induced ; Disease Models, Animal ; Free Radicals - pharmacology ; Humans ; Mice ; Mice, Inbred NOD ; Rats ; Rats, Inbred BB ; Streptozocin - pharmacology
É parte de: Orvosi hetilap, 1996-08, Vol.137 (34), p.1865
Descrição: The authors review the knowledge accumulated on animal models of diabetes during the last decade. The most commonly used diabetes models and the underlying disease processes are summarized, respectively. The best known diabetogenic substances, Streptozotocin and Alloxan are described, including their usage, dosage dosing intervals, and mechanism of action. The latest results are included in the article which discuss the possible role of free radical-induced injury of beta cells in Streptozotocin and Alloxan diabetes.
Editor: Hungary
Idioma: Húngaro

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