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Cisplatin-resistant human small cell lung cancer cell line shows collateral sensitivity to vinca alkaloids

Moritaka, T ; Kiura, K ; Ueoka, H ; Tabata, M ; Segawa, Y ; Shibayama, T ; Takigawa, N ; Ohnoshi, T ; Harada, M

Anticancer research, 1998-03, Vol.18 (2A), p.927 [Periódico revisado por pares]

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Título:
Cisplatin-resistant human small cell lung cancer cell line shows collateral sensitivity to vinca alkaloids
Autor: Moritaka, T ; Kiura, K ; Ueoka, H ; Tabata, M ; Segawa, Y ; Shibayama, T ; Takigawa, N ; Ohnoshi, T ; Harada, M
Assuntos: Antineoplastic Agents - pharmacology ; ATP-Binding Cassette, Sub-Family B, Member 1 - analysis ; Carcinoma, Small Cell - drug therapy ; Carcinoma, Small Cell - pathology ; Cisplatin - pharmacology ; DNA Topoisomerases, Type I - metabolism ; DNA Topoisomerases, Type II - metabolism ; Drug Resistance, Neoplasm ; Glutathione - analysis ; Humans ; Lung Neoplasms - drug therapy ; Lung Neoplasms - pathology ; Tumor Cells, Cultured ; Vincristine - pharmacokinetics ; Vincristine - pharmacology
É parte de: Anticancer research, 1998-03, Vol.18 (2A), p.927
Descrição: A cisplatin-resistant cell line, SBC-3/CDDP, was established from a human small-cell lung cancer cell line, SBC-3. The SBC-3/CDDP cells were 13.1-fold more resistant to cisplatin than the parent SBC-3 cells. We investigated the cellular changes of this cell line with regard to the development of resistance to cisplatin. The SBC-3/CDDP cells showed various characteristics as follows: a) increased intracellular glutathione and glutathione S-transferase content b) decreased intracellular accumulation of cisplatin, c) increased topoisomerase I activity and the same topoisomerase II activity as the parent SBC-3 cells, and 4) strong cross-resistance to the platinum analogues and mitomycin C, moderate cross-resistance to 7-ethyl-10-hydroxy-camptothecin (SN-38), 4-hydroperoxy cyclophosphamide, etoposide, Adriamycin and methotrexate, and collateral sensitivity to vinca alkaloids and 5-fluorouracil. From these observations, the SBC-3/CDDP cells could be useful as a well characterized cisplatin-resistant cell line, and the resistance pattem in this cell line will give us much information for eradication of cisplatin-resistant tumor cells.
Editor: Greece
Idioma: Inglês

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Cisplatin-resistant human small cell lung cancer cell line shows collateral sensitivity to vinca alkaloids

Moritaka, T ; Kiura, K ; Ueoka, H ; Tabata, M ; Segawa, Y ; Shibayama, T ; Takigawa, N ; Ohnoshi, T ; Harada, M

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