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B1 Field inhomogeneity correction for qDESS T2 mapping: application to rapid bilateral knee imaging

Barbieri, Marco ; Watkins, Lauren E. ; Mazzoli, Valentina ; Desai, Arjun D. ; Rubin, Elka ; Schmidt, Andrew ; Gold, Garry Evan ; Hargreaves, Brian Andrew ; Chaudhari, Akshay Sanjay ; Kogan, Feliks

Magma (New York, N.Y.), 2023-10, Vol.36 (5), p.711-724 [Periódico revisado por pares]

Cham: Springer International Publishing

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  • Título:
    B1 Field inhomogeneity correction for qDESS T2 mapping: application to rapid bilateral knee imaging
  • Autor: Barbieri, Marco ; Watkins, Lauren E. ; Mazzoli, Valentina ; Desai, Arjun D. ; Rubin, Elka ; Schmidt, Andrew ; Gold, Garry Evan ; Hargreaves, Brian Andrew ; Chaudhari, Akshay Sanjay ; Kogan, Feliks
  • Assuntos: Basic Science - Parametric mapping and quantitative MRI ; Biomedical Engineering and Bioengineering ; Computer Appl. in Life Sciences ; Health Informatics ; Imaging ; Medicine ; Medicine & Public Health ; Radiology ; Research Article ; Solid State Physics
  • É parte de: Magma (New York, N.Y.), 2023-10, Vol.36 (5), p.711-724
  • Notas: Author Contributions MB—study conception and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, and critical revision. LEW—study conception and design, acquisition of data and critical revision. VM—study conception and design, and critical revision. ADD—critical revision. ER—acquisition of data. AS—acquisition of the data. GEG—critical revision. BAH—study conception and critical revision. ASC—study conception and critical revision. FK—study conception and design, and critical revision.
  • Descrição: Purpose T 2 mapping is a powerful tool for studying osteoarthritis (OA) changes and bilateral imaging may be useful in investigating the role of between-knee asymmetry in OA onset and progression. The quantitative double-echo in steady-state (qDESS) can provide fast simultaneous bilateral knee T 2 and high-resolution morphometry for cartilage and meniscus. The qDESS uses an analytical signal model to compute T 2 relaxometry maps, which require knowledge of the flip angle (FA). In the presence of B 1 inhomogeneities, inconsistencies between the nominal and actual FA can affect the accuracy of T 2 measurements. We propose a pixel-wise B 1 correction method for qDESS T 2 mapping exploiting an auxiliary B 1 map to compute the actual FA used in the model. Methods The technique was validated in a phantom and in vivo with simultaneous bilateral knee imaging. T 2 measurements of femoral cartilage (FC) of both knees of six healthy participants were repeated longitudinally to investigate the association between T 2 variation and B 1 . Results The results showed that applying the B 1 correction mitigated T 2 variations that were driven by B 1 inhomogeneities. Specifically, T 2 left–right symmetry increased following the B 1 correction ( ρ c = 0.74 > ρ c = 0.69). Without the B 1 correction, T 2 values showed a linear dependence with B 1 . The linear coefficient decreased using the B 1 correction (from 24.3 ± 1.6 ms to 4.1 ± 1.8) and the correlation was not statistically significant after the application of the Bonferroni correction ( p value > 0.01). Conclusion The study showed that B 1 correction could mitigate variations driven by the sensitivity of the qDESS T 2 mapping method to B 1 , therefore, increasing the sensitivity to detect real biological changes. The proposed method may improve the robustness of bilateral qDESS T 2 mapping, allowing for an accurate and more efficient evaluation of OA pathways and pathophysiology through longitudinal and cross-sectional studies.
  • Editor: Cham: Springer International Publishing
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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