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Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study

Jowett, S L ; Seal, C J ; Pearce, M S ; Phillips, E ; Gregory, W ; Barton, J R ; Welfare, M R

Gut, 2004-10, Vol.53 (10), p.1479-1484 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

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Título:
Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study
Autor: Jowett, S L ; Seal, C J ; Pearce, M S ; Phillips, E ; Gregory, W ; Barton, J R ; Welfare, M R
Assuntos: Adult ; Alcohol ; Alcohol Drinking - adverse effects ; Amino acids ; Bacteria ; basal metabolic rate ; BMR ; cohort study ; Colitis, Ulcerative - etiology ; Colon ; Dairy products ; Diet ; Diet - adverse effects ; Female ; FFQ ; Food ; food frequency questionnaire ; Histology ; Humans ; Inflammatory Bowel Disease ; interquartile range ; IQR ; Logistic Models ; Male ; Meat ; Meat - adverse effects ; Meat products ; Middle Aged ; Nutrition Assessment ; Nutrition research ; Odds Ratio ; PAL ; physical activity level ; Prospective Studies ; Proteins ; Recurrence ; Risk Factors ; SCCAI ; simple clinical colitis activity index ; Studies ; Sulfur ; sulphur ; ulcerative colitis
É parte de: Gut, 2004-10, Vol.53 (10), p.1479-1484
Notas: istex:C77A04BFC90DB57F3FAEBCE0F98DEA11EB38FE40
Correspondence to:  Dr M R Welfare  University of Newcastle, North Tyneside Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, UK; mark.welfare@northumbria-healthcare.nhs.uk
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Correspondence to: Dr M R Welfare University of Newcastle, North Tyneside Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, UK; mark.welfare@northumbria-healthcare.nhs.uk
Descrição: Background and aims: The causes of relapses of ulcerative colitis (UC) are unknown. Dietary factors have been implicated in the pathogenesis of UC. The aim of this study was to determine which dietary factors are associated with an increased risk of relapse of UC. Methods: A prospective cohort study was performed with UC patients in remission, recruited from two district general hospitals, who were followed for one year to determine the effect of habitual diet on relapse. Relapse was defined using a validated disease activity index. Nutrient intake was assessed using a food frequency questionnaire and categorised into tertiles. Adjusted odds ratios for relapse were determined using multivariate logistic regression, controlling for non-dietary factors. Results: A total of 191 patients were recruited and 96% completed the study. Fifty two per cent of patients relapsed. Consumption of meat (odds ratio (OR) 3.2 (95% confidence intervals (CI) 1.3–7.8)), particularly red and processed meat (OR 5.19 (95% CI 2.1–12.9)), protein (OR 3.00 (95% CI 1.25–7.19)), and alcohol (OR 2.71 (95% CI 1.1–6.67)) in the top tertile of intake increased the likelihood of relapse compared with the bottom tertile of intake. High sulphur (OR 2.76 (95% CI 1.19–6.4)) or sulphate (OR 2.6 (95% CI 1.08–6.3)) intakes were also associated with relapse and may offer an explanation for the observed increased likelihood of relapse. Conclusions: Potentially modifiable dietary factors, such as a high meat or alcoholic beverage intake, have been identified that are associated with an increased likelihood of relapse for UC patients. Further studies are needed to determine if it is the sulphur compounds within these foods that mediates the likelihood of relapse and if reducing their intake would reduce relapse frequency.
Editor: England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Idioma: Inglês

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Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study

Jowett, S L ; Seal, C J ; Pearce, M S ; Phillips, E ; Gregory, W ; Barton, J R ; Welfare, M R

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

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