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A pilot study in patients with established advanced liver fibrosis using pirfenidone

Armendáriz-Borunda, J ; Islas-Carbajal, M C ; Meza-García, E ; Rincón, A R ; Lucano, S ; Sandoval, A S ; Salazar, A ; Berumen, J ; Alvarez, A ; Covarrubias, A ; Aréchiga, G ; García, L

Gut, 2006-11, Vol.55 (11), p.1663-1665 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

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Título:
A pilot study in patients with established advanced liver fibrosis using pirfenidone
Autor: Armendáriz-Borunda, J ; Islas-Carbajal, M C ; Meza-García, E ; Rincón, A R ; Lucano, S ; Sandoval, A S ; Salazar, A ; Berumen, J ; Alvarez, A ; Covarrubias, A ; Aréchiga, G ; García, L
Assuntos: Aged ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biopsy ; Clinical trials ; Female ; Flow velocity ; Gangrene ; Gene expression ; Genotype & phenotype ; Hepatitis ; Hepatitis C, Chronic - complications ; Humans ; Inflammation ; Letters ; Liver ; Liver Cirrhosis - drug therapy ; liver fibrosis ; Male ; Middle Aged ; Mortality ; Patients ; Pilot Projects ; pirfenidone ; Pyridones - therapeutic use ; Treatment Outcome
É parte de: Gut, 2006-11, Vol.55 (11), p.1663-1665
Notas: istex:0F51EBABB34E8EB7E3DCCA4DD2F9CEC53A1E159F
PMID:17047115
local:0551663
Correspondence to:  Dr J Armendáriz-Borunda  Institute for Molecular Biology in Medicine and Gene Therapy, Apdo Postal 2-123, Guadalajara, Jalisco, México 44281; armendbo@cucs.udg.mx
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Descrição: PFD is an orally bioavailable pyridone derivative (5-methyl-1-phenyl-2-(1H)-pyridone) that affects a variety of profibrogenic cytokines and its mechanism of action mostly resides in its anti-inflammatory and antifibrotic activity. 4- 6 Here we present data obtained from a pilot clinical trial evaluating the safety and efficacy of PFD in 15 patients with established advanced liver disease caused by hepatitis C virus chronic infection. An SF-36 survey, self-administered by patients, demonstrated an improvement in quality of life. 7 Real Time PCR was used to detect gene expression of key molecules involved in collagen turnover. mRNAs coding for profibrogenic molecules such as Col Î±1, transforming growth factor Î², and tissue inhibitor of metalloproteinase 1 were markedly downregulated at the end of treatment.
Editor: England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Idioma: Inglês

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A pilot study in patients with established advanced liver fibrosis using pirfenidone

Armendáriz-Borunda, J ; Islas-Carbajal, M C ; Meza-García, E ; Rincón, A R ; Lucano, S ; Sandoval, A S ; Salazar, A ; Berumen, J ; Alvarez, A ; Covarrubias, A ; Aréchiga, G ; García, L

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

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