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Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study

Kadri, Z ; Danchin, N ; Vaur, L ; Cottin, Y ; Guéret, P ; Zeller, M ; Lablanche, J-M ; Blanchard, D ; Hanania, G ; Genès, N ; Cambou, J-P

Heart (British Cardiac Society), 2006-07, Vol.92 (7), p.910-915 [Periódico revisado por pares]

London: BMJ Publishing Group Ltd and British Cardiovascular Society

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Título:
Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study
Autor: Kadri, Z ; Danchin, N ; Vaur, L ; Cottin, Y ; Guéret, P ; Zeller, M ; Lablanche, J-M ; Blanchard, D ; Hanania, G ; Genès, N ; Cambou, J-P
Assuntos: acute myocardial infarction ; AMI ; Biological and medical sciences ; Blood Glucose - analysis ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular Medicine ; confidence interval ; Coronary heart disease ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; France - epidemiology ; Glucose ; glycaemia ; Heart ; Heart attacks ; Heart failure ; Heart rate ; Hospital Mortality ; Hospitalization ; Humans ; Intensive care ; left ventricular failure ; Male ; Medical sciences ; Methods ; Middle Aged ; Mortality ; Multivariate Analysis ; Myocardial Infarction - blood ; Myocardial Infarction - mortality ; Myocarditis. Cardiomyopathies ; Patients ; Prognosis ; Regression analysis ; ST elevation myocardial infarction ; STEMI ; Survival Analysis ; Variables
É parte de: Heart (British Cardiac Society), 2006-07, Vol.92 (7), p.910-915
Notas: ark:/67375/NVC-VBQHLS0R-6
PMID:16339808
Correspondence to:  Professor Nicolas Danchin  Department of Cardiology, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France; nicolas.danchin@egp.ap-hop-paris.fr
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href:heartjnl-92-910.pdf
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Descrição: Objective: To analyse the short and long term prognostic significance of admission glycaemia in a large registry of non-diabetic patients with acute myocardial infarction. Methods: Assessment of short and long term prognostic significance of admission blood glucose in a consecutive population of 1604 non-diabetic patients admitted to intensive care units in France in November 2000 for a recent (⩽ 48 hours) myocardial infarction. Results: In-hospital mortality, compared with that of patients with admission glycaemia below the median value of 6.88 mmol/l (3.7%), rose gradually with each of the three upper sextiles of glycaemia: 6.5%, 12.5% and 15.2%. Conversely, one year survival decreased from 92.5% to 88%, 83% and 75% (p < 0.001). Admission glycaemia remained an independent predictor of in-hospital and one year mortality after multivariate analyses accounting for potential confounders. Increased admission glycaemia also was a predictor of poor outcome in all clinical subsets studied: patients without heart failure on admission, younger and older patients, patients with or without reperfusion therapy, and patients with or without ST segment elevation. Conclusion: In non-diabetic patients, raised admission blood glucose is a strong and independent predictor of both in-hospital and long term mortality.
Editor: London: BMJ Publishing Group Ltd and British Cardiovascular Society
Idioma: Inglês

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Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study

Kadri, Z ; Danchin, N ; Vaur, L ; Cottin, Y ; Guéret, P ; Zeller, M ; Lablanche, J-M ; Blanchard, D ; Hanania, G ; Genès, N ; Cambou, J-P

London: BMJ Publishing Group Ltd and British Cardiovascular Society

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