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Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkeys

De Brito, T ; Gunji, J ; Camargo, M E ; Ceravolo, A ; Da Silva, L C

Bulletin of the World Health Organization, 1971, Vol.45 (4), p.419-422 [Periódico revisado por pares]

Switzerland

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Título:
Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkeys
Autor: De Brito, T ; Gunji, J ; Camargo, M E ; Ceravolo, A ; Da Silva, L C
Assuntos: Animals ; Antigen-Antibody Complex ; Basement Membrane - immunology ; Fluorescent Antibody Technique ; gamma-Globulins - analysis ; Haplorhini ; Kidney Diseases - etiology ; Kidney Diseases - immunology ; Kidney Diseases - pathology ; Kidney Glomerulus - pathology ; Microscopy, Electron ; Schistosoma mansoni ; Schistosomiasis - complications ; Schistosomiasis - pathology
É parte de: Bulletin of the World Health Organization, 1971, Vol.45 (4), p.419-422
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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From the Instituto de Medicina Tropical de São Paulo and the Hospital das Clinícas, University of São Paulo, São Paulo, Brazil. This work was supported by grants from the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia and the Fundaçâo de Amparo à Pesquisa do Estado de São Paulo.
Descrição: Three monkeys (Cebus apella) experimentally infected with Schistosoma mansoni studied for periods of 19, 14, and 11 months showed deposits containing gamma-globulin in subendothelial and subepithelial basal membranes and in basement membranes proper. The glomeruli showed mild reactivity characterized by local hypertrophy and hyperplasia of mesangial cells. Such findings were close to those observed by us in the kidney of hepatosplenic schistosomiasis patients without evidence of renal disease. The distribution of the deposits, both in human and experimental disease, are suggestive of preformed, non-glomerular antigen-antibody complexes that form in a zone of excess antigen and become trapped in the glomerular capillaries.The possibility exists, but has not yet been proved beyond doubt, that renal disease in schistosomiasis patients could be the end result of this pathogenetic mechanism.
Editor: Switzerland
Idioma: Inglês

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Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkeys

De Brito, T ; Gunji, J ; Camargo, M E ; Ceravolo, A ; Da Silva, L C

Switzerland

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