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Optimal antibiotic therapy in cholera

Wallace, C K ; Anderson, P N ; Brown, T C ; Khanra, S R ; Lewis, G W ; Pierce, N F ; Sanyal, S N ; Segre, G V ; Waldman, R H

Bulletin of the World Health Organization, 1968, Vol.39 (2), p.239-245 [Periódico revisado por pares]

Switzerland

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  • Título:
    Optimal antibiotic therapy in cholera
  • Autor: Wallace, C K ; Anderson, P N ; Brown, T C ; Khanra, S R ; Lewis, G W ; Pierce, N F ; Sanyal, S N ; Segre, G V ; Waldman, R H
  • Assuntos: Adolescent ; Adult ; Chloramphenicol - therapeutic use ; Cholera - drug therapy ; Clinical Trials as Topic ; Humans ; India ; Male ; Middle Aged ; Sulfaguanidine - therapeutic use ; Tetracycline - administration & dosage
  • É parte de: Bulletin of the World Health Organization, 1968, Vol.39 (2), p.239-245
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
    This work was supported in part by US Public Health Service Research Grant No. H. 26.6217.08 and in part by funding under Public Law 480, Section 104 (C), Agreement No. 5 × 3417, and was carried out at the Johns Hopkins University Center for Medical Research and Training, School of Tropical Medicine, and Infectious Diseases Hospital, Calcutta, India.
  • Descrição: Intravenous replacement of the diarrhoeal fluid and electrolyte losses to restore a physiological state of hydration is well established as the basis for successful management of cholera patients. The use of oral tetracycline as an adjunct in reducing the volume and duration of diarrhoea, as well as eradicating the vibrio from the gastrointestinal tract, has been proven beneficial. An optimal dose schedule has not been established previously, and clinical or bacteriological relapses have been generally reported. Chloramphenicol and sulfaguanidine have also been mentioned as adjuncts. The present report shows that 3 g or 4 g of tetracycline in one of 3 dose schedules were predictably efficacious. Chloramphenicol, while of benefit, was not as effective and sulfaguanidine was of little benefit compared with the tetracycline regimens.
  • Editor: Switzerland
  • Idioma: Inglês
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