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A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy

Hajek, Tomas, MD, PhD ; Bernier, Denise, BSc ; Slaney, Claire, RN ; Propper, Lukas, MD ; Schmidt, Matthias, MD ; Carrey, Normand, MD ; MacQueen, Glenda, MD, PhD ; Duffy, Anne, MD ; Alda, Martin, MD

Journal of psychiatry & neuroscience, 2008-11, Vol.33 (6), p.531-540 [Periódico revisado por pares]

Ottawa, ON: Canadian Medical Association

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Título:
A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy
Autor: Hajek, Tomas, MD, PhD ; Bernier, Denise, BSc ; Slaney, Claire, RN ; Propper, Lukas, MD ; Schmidt, Matthias, MD ; Carrey, Normand, MD ; MacQueen, Glenda, MD, PhD ; Duffy, Anne, MD ; Alda, Martin, MD
Assuntos: Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Biomarkers ; Bipolar disorder ; Bipolar Disorder - genetics ; Bipolar Disorder - metabolism ; Bipolar Disorder - psychology ; Bipolar disorders ; Brain Chemistry ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genetic disorders ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Medical Education ; Medical sciences ; Methods ; Mood disorders ; Mood Disorders - metabolism ; Mood Disorders - psychology ; NMR ; Nuclear magnetic resonance ; Observations ; Prefrontal cortex ; Proton magnetic resonance spectroscopy ; Psychiatric Status Rating Scales ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Paper ; Studies
É parte de: Journal of psychiatry & neuroscience, 2008-11, Vol.33 (6), p.531-540
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Objective Bipolar disorders have a strong genetic underpinning. Little is known about biological predispositions that convey vulnerability for the illness. We searched for biological vulnerability markers using proton magnetic resonance spectroscopy (MRS) in both affected and unaffected participants at high genetic risk for bipolar disorder. Methods We recruited high-risk participants aged 15–30 years from families in which multiple members were affected with bipolar disorder. Our primary sample included 14 affected and 15 unaffected relatives of probands with bipolar I disorder. Our extended sample comprised 19 affected and 21 unaffected participants with a family history of either bipolar I or bipolar II disorders. We matched both samples by age and sex with 31 control participants without a personal or family history of psychiatric disorders. We performed single voxel proton MRS at 1.5 T in bilateral dorsal and ventral medial prefrontal cortices with correction for grey matter proportion. Results We found comparable levels of choline, creatine, myo-inositol and N-acetylaspartate among the groups in both samples. There were no differences between regions of the medial prefrontal cortex or between hemispheres for any of the metabolites in any of the samples. The exclusion of 5 participants taking medication did not change our results. Conclusion Neurochemical changes in the medial prefrontal cortex that are measurable using proton MRS do not appear to be antecedent to the onset of mood disorders in genetically susceptible individuals.
Editor: Ottawa, ON: Canadian Medical Association
Idioma: Francês;Inglês

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A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy

Hajek, Tomas, MD, PhD ; Bernier, Denise, BSc ; Slaney, Claire, RN ; Propper, Lukas, MD ; Schmidt, Matthias, MD ; Carrey, Normand, MD ; MacQueen, Glenda, MD, PhD ; Duffy, Anne, MD ; Alda, Martin, MD

Ottawa, ON: Canadian Medical Association

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