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Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection

Ceravolo, I.P ; Sanchez, B.A.M ; Sousa, T.N ; Guerra, B.M ; Soares, I.S ; Braga, E.M ; McHenry, A.M ; Adams, J.H ; Brito, C.F.A ; Carvalho, L.H

Clinical and experimental immunology, 2009-06, Vol.156 (3), p.502-510 [Peer Reviewed Journal]

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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Title:
Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection
Author: Ceravolo, I.P ; Sanchez, B.A.M ; Sousa, T.N ; Guerra, B.M ; Soares, I.S ; Braga, E.M ; McHenry, A.M ; Adams, J.H ; Brito, C.F.A ; Carvalho, L.H
Subjects: Adult ; allele-specific ; Alleles ; Analytical, structural and metabolic biochemistry ; Animals ; Antibodies, Protozoan - blood ; antibody response ; Antigens, Protozoan - genetics ; Antigens, Protozoan - immunology ; Biological and medical sciences ; Brazil - epidemiology ; Cross-Sectional Studies ; Disease Outbreaks ; DNA, Protozoan - genetics ; duffy binding protein ; Fundamental and applied biological sciences. Psychology ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Malaria, Vivax - epidemiology ; Malaria, Vivax - immunology ; Malaria, Vivax - parasitology ; Medical sciences ; Merozoite Surface Protein 1 - immunology ; Middle Aged ; Parasitic diseases ; Plasmodium vivax ; Plasmodium vivax - genetics ; Plasmodium vivax - immunology ; Protozoal diseases ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - immunology ; Translational Studies ; Young Adult
Is Part Of: Clinical and experimental immunology, 2009-06, Vol.156 (3), p.502-510
Notes: http://dx.doi.org/10.1111/j.1365-2249.2009.03931.x
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Description: The Duffy binding protein of Plasmodium vivax (DBP) is a critical adhesion ligand that participates in merozoite invasion of human Duffy-positive erythrocytes. A small outbreak of P. vivax malaria, in a village located in a non-malarious area of Brazil, offered us an opportunity to investigate the DBP immune responses among individuals who had their first and brief exposure to malaria. Thirty-three individuals participated in the five cross-sectional surveys, 15 with confirmed P. vivax infection while residing in the outbreak area (cases) and 18 who had not experienced malaria (non-cases). In the present study, we found that only 20% (three of 15) of the individuals who experienced their first P. vivax infection developed an antibody response to DBP; a secondary boosting can be achieved with a recurrent P. vivax infection. DNA sequences from primary/recurrent P. vivax samples identified a single dbp allele among the samples from the outbreak area. To investigate inhibitory antibodies to the ligand domain of the DBP (cysteine-rich region II, DBPII), we performed in vitro assays with mammalian cells expressing DBPII sequences which were homologous or not to those from the outbreak isolate. In non-immune individuals, the results of a 12-month follow-up period provided evidence that naturally acquired inhibitory antibodies to DBPII are short-lived and biased towards a specific allele.
Publisher: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Language: English

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Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection

Ceravolo, I.P ; Sanchez, B.A.M ; Sousa, T.N ; Guerra, B.M ; Soares, I.S ; Braga, E.M ; McHenry, A.M ; Adams, J.H ; Brito, C.F.A ; Carvalho, L.H

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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