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Pathological and protective roles of glia in chronic pain

Milligan, Erin D ; Watkins, Linda R

Nature reviews. Neuroscience, 2009-01, Vol.10 (1), p.23-36 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Pathological and protective roles of glia in chronic pain
Autor: Milligan, Erin D ; Watkins, Linda R
Assuntos: Animals ; Biological and medical sciences ; Cell Communication - physiology ; Chemokines ; Chronic Disease ; Chronic pain ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Cytokines ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation ; Medical sciences ; Models, Biological ; Nervous system (semeiology, syndromes) ; Neural transmission ; Neuroglia ; Neuroglia - cytology ; Neuroglia - physiology ; Neurology ; Neurons ; Neurons - cytology ; Neurons - physiology ; Neurosciences ; Neurotoxicity ; Pain ; Pain - pathology ; Pain - physiopathology ; Physiological aspects ; Risk factors ; Signal Transduction - physiology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal cord ; Vertebrates: nervous system and sense organs
É parte de: Nature reviews. Neuroscience, 2009-01, Vol.10 (1), p.23-36
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions. Here we review the current understanding of the contribution of glia to pathological pain and neuroprotection, and how the protective, anti-inflammatory actions of glia are being harnessed to develop new drug targets for neuropathic pain control. Given the prevalence of chronic pain and the partial efficacy of current drugs, which exclusively target neuronal mechanisms, new strategies to manipulate neuron-glia interactions in pain processing hold considerable promise.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Pathological and protective roles of glia in chronic pain

Milligan, Erin D ; Watkins, Linda R

London: Nature Publishing Group

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