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Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan‐induced knee joint synovitis in the rat

Ekundi‐Valentim, E ; Santos, KT ; Camargo, EA ; Denadai‐Souza, A ; Teixeira, SA ; Zanoni, CI ; Grant, AD ; Wallace, JL ; Muscará, MN ; Costa, SK

British journal of pharmacology, 2010-04, Vol.159 (7), p.1463-1474 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan‐induced knee joint synovitis in the rat
Autor: Ekundi‐Valentim, E ; Santos, KT ; Camargo, EA ; Denadai‐Souza, A ; Teixeira, SA ; Zanoni, CI ; Grant, AD ; Wallace, JL ; Muscará, MN ; Costa, SK
Assuntos: Animals ; Biological and medical sciences ; carrageenan ; Carrageenan - adverse effects ; Hydrogen Sulfide - pharmacology ; hydrogen sulphide ; IL‐1β ; Knee ; Knee Joint - enzymology ; Knee Joint - metabolism ; Knee Joint - pathology ; Lawesson's reagent ; Male ; Medical sciences ; neutrophils ; nitric oxide ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase Type II - metabolism ; Pain ; Peroxidase - metabolism ; Pharmacology. Drug treatments ; rat ; Rats ; Rats, Wistar ; Research Papers ; Rodents ; secondary tactile allodynia ; synovitis ; Synovitis - chemically induced ; Synovitis - enzymology ; Synovitis - metabolism ; Tyrosine - analogs & derivatives ; Tyrosine - metabolism
É parte de: British journal of pharmacology, 2010-04, Vol.159 (7), p.1463-1474
Descrição: Background and purpose: Recent findings suggest that the noxious gas H2S is produced endogenously, and that physiological concentrations of H2S are able to modulate pain and inflammation in rodents. This study was undertaken to evaluate the ability of endogenous and exogenous H2S to modulate carrageenan‐induced synovitis in the rat knee. Experimental approach: Synovitis was induced in Wistar rats by intra‐articular injection of carrageenan into the knee joint. Sixty minutes prior to carrageenan injection, the rats were pretreated with indomethacin, an inhibitor of H2S formation (dl‐propargylglycine) or an H2S donor [Lawesson's reagent (LR)]. Key results: Injection of carrageenan evoked knee inflammation, pain as characterized by impaired gait, secondary tactile allodynia of the ipsilateral hindpaw, joint swelling, histological changes, inflammatory cell infiltration, increased synovial myeloperoxidase, protein nitrotyrosine residues, inducible NOS (iNOS) activity and NO production. Pretreatment with LR or indomethacin significantly attenuated the pain responses, and all the inflammatory and biochemical changes, except for the increased iNOS activity, NO production and 3‐NT. Propargylglycine pretreatment potentiated synovial iNOS activity (and NO production), and enhanced macrophage infiltration, but had no effect on other inflammatory parameters. Conclusions and implications: Whereas exogenous H2S delivered to the knee joint can produce a significant anti‐inflammatory and anti‐nociceptive effect, locally produced H2S exerts little immunomodulatory effect. These data further support the development and use of H2S donors as potential alternatives (or complementary therapies) to the available anti‐inflammatory compounds used for treatment of joint inflammation or relief of its symptoms.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan‐induced knee joint synovitis in the rat

Ekundi‐Valentim, E ; Santos, KT ; Camargo, EA ; Denadai‐Souza, A ; Teixeira, SA ; Zanoni, CI ; Grant, AD ; Wallace, JL ; Muscará, MN ; Costa, SK

Oxford, UK: Blackwell Publishing Ltd

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