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Mediator and cohesin connect gene expression and chromatin architecture

Taatjes, Dylan J ; van Berkum, Nynke L ; Young, Richard A ; Kagey, Michael H ; Bilodeau, Steve ; Zhan, Ye ; Ebmeier, Christopher C ; Levine, Stuart S ; Newman, Jamie J ; Rahl, Peter B ; Dekker, Job ; Goossens, Jesse ; Orlando, David A

Nature (London), 2010-09, Vol.467 (7314), p.430-435 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Mediator and cohesin connect gene expression and chromatin architecture
Autor: Taatjes, Dylan J ; van Berkum, Nynke L ; Young, Richard A ; Kagey, Michael H ; Bilodeau, Steve ; Zhan, Ye ; Ebmeier, Christopher C ; Levine, Stuart S ; Newman, Jamie J ; Rahl, Peter B ; Dekker, Job ; Goossens, Jesse ; Orlando, David A
Assuntos: Animals ; Biological and medical sciences ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cells, Cultured ; Chromatin ; Chromatin - chemistry ; Chromatin - genetics ; Chromatin - metabolism ; Chromatin Assembly and Disassembly - genetics ; Chromatin. Chromosome ; Chromosomal Proteins, Non-Histone - genetics ; Chromosomal Proteins, Non-Histone - metabolism ; Cohesins ; Cytogenetics ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; DNA - genetics ; DNA - metabolism ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - metabolism ; Enhancer Elements, Genetic - genetics ; Fibroblasts ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation - genetics ; Mediator Complex - genetics ; Mediator Complex - metabolism ; Mice ; Molecular and cellular biology ; Molecular genetics ; Mutation ; Nucleic Acid Conformation ; Organ Specificity ; Physiological aspects ; Promoter Regions, Genetic - genetics ; Properties ; Protein Binding ; Proteins ; RNA polymerase ; Transcription factors
É parte de: Nature (London), 2010-09, Vol.467 (7314), p.430-435
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work
Descrição: Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound transcription factors and the transcription apparatus at the core promoter, but this process is not well understood. Here we report that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells. Mediator, a transcriptional coactivator, forms a complex with cohesin, which can form rings that connect two DNA segments. The cohesin-loading factor Nipbl is associated with mediator-cohesin complexes, providing a means to load cohesin at promoters. DNA looping is observed between the enhancers and promoters occupied by mediator and cohesin. Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Mediator and cohesin connect gene expression and chromatin architecture

Taatjes, Dylan J ; van Berkum, Nynke L ; Young, Richard A ; Kagey, Michael H ; Bilodeau, Steve ; Zhan, Ye ; Ebmeier, Christopher C ; Levine, Stuart S ; Newman, Jamie J ; Rahl, Peter B ; Dekker, Job ; Goossens, Jesse ; Orlando, David A

London: Nature Publishing Group

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