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Sibling Recurrence and the Genetic Epidemiology of Autism

Constantino, John N. ; Zhang, Yi ; Frazier, Thomas ; Abbacchi, Anna M. ; Law, Paul

The American journal of psychiatry, 2010-11, Vol.167 (11), p.1349-1356 [Periódico revisado por pares]

Arlington, VA: American Psychiatric Publishing

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Título:
Sibling Recurrence and the Genetic Epidemiology of Autism
Autor: Constantino, John N. ; Zhang, Yi ; Frazier, Thomas ; Abbacchi, Anna M. ; Law, Paul
Assuntos: Adolescent ; Autism ; Biological and medical sciences ; Child ; Child clinical studies ; Child Development Disorders, Pervasive - diagnosis ; Child Development Disorders, Pervasive - epidemiology ; Child Development Disorders, Pervasive - genetics ; Child Development Disorders, Pervasive - psychology ; Child, Preschool ; Children & youth ; Data collection ; Developmental disorders ; Female ; Genetic counseling ; Genetics ; Humans ; Independent sample ; Infantile autism ; Language Development Disorders - diagnosis ; Language Development Disorders - epidemiology ; Language Development Disorders - genetics ; Language Development Disorders - psychology ; Male ; Medical sciences ; Molecular Epidemiology ; Mutation ; Phenotype ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Quantitative Trait, Heritable ; Recurrence ; Registries ; Risk ; Sex Factors ; Siblings ; Speech Disorders - diagnosis ; Speech Disorders - epidemiology ; Speech Disorders - genetics ; Speech Disorders - psychology ; United States
É parte de: The American journal of psychiatry, 2010-11, Vol.167 (11), p.1349-1356
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objective:Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings. Method:The authors report the results of quantitative characterization of 2,920 children from 1,235 families participating in a national volunteer register, with at least one child clinically affected by an autism spectrum disorder and at least one full biological sibling. Results:A traditionally defined autism spectrum disorder in an additional child occurred in 10.9% of the families. An additional 20% of nonautism-affected siblings had a history of language delay, one-half of whom exhibited autistic qualities of speech. Quantitative characterization using the Social Responsiveness Scale supported previously reported aggregation of a wide range of subclinical (quantitative) autistic traits among otherwise unaffected children in multiple-incidence families and a relative absence of quantitative autistic traits among siblings in single-incidence families. Girls whose standardized severity ratings fell above a first percentile severity threshold (relative to the general population distribution) were significantly less likely to have elicited community diagnoses than their male counterparts. Conclusions:These data suggest that, depending on how it is defined, sibling recurrence in autism spectrum disorder may exceed previously published estimates and varies as a function of family type. The results support differences in mechanisms of genetic transmission between simplex and multiplex autism and advance current understanding of the genetic epidemiology of autism spectrum conditions.
Editor: Arlington, VA: American Psychiatric Publishing
Idioma: Inglês

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Sibling Recurrence and the Genetic Epidemiology of Autism

Constantino, John N. ; Zhang, Yi ; Frazier, Thomas ; Abbacchi, Anna M. ; Law, Paul

Arlington, VA: American Psychiatric Publishing

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