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Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone- co - p -dioxanone) copolyesters

Liu, Jie ; Jiang, Zhaozhong ; Zhang, Shengmin ; Liu, Chen ; Gross, Richard A ; Kyriakides, Themis R ; Saltzman, W. Mark

Biomaterials, 2011-09, Vol.32 (27), p.6646-6654 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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Título:
Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone- co - p -dioxanone) copolyesters
Autor: Liu, Jie ; Jiang, Zhaozhong ; Zhang, Shengmin ; Liu, Chen ; Gross, Richard A ; Kyriakides, Themis R ; Saltzman, W. Mark
Assuntos: Advanced Basic Science ; Animals ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biodegradable nanoparticles ; Biodegradation, Environmental - drug effects ; Dentistry ; Dioxanes - chemical synthesis ; Dioxanes - chemistry ; Doxorubicin ; Doxorubicin - pharmacology ; Drug delivery ; Drug Delivery Systems - methods ; Foreign-Body Reaction - pathology ; Gene Expression - drug effects ; Gene Silencing - drug effects ; Hydrolysis - drug effects ; Luciferases - genetics ; Luciferases - metabolism ; Materials Testing ; Mice ; Molecular Weight ; Nanoparticles - ultrastructure ; Particle Size ; Poly(ω-pentadecalactone-co-p-dioxanone) ; Polyesters - chemical synthesis ; Polyesters - chemistry ; RNA, Small Interfering - metabolism ; siRNA ; Spermidine - chemistry
É parte de: Biomaterials, 2011-09, Vol.32 (27), p.6646-6654
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Poly(ω-pentadecalactone- co - p -dioxanone) [poly(PDL- co -DO)] copolyesters are copolymers of an isodimorphic system, which remain semicrystalline over the whole range of compositions. Here, we evaluated enzymatically synthesized poly(PDL- co -DO) copolymers as new materials for biomedical applications. In vivo experiments using mice, showed that the copolyesters are well tolerated, with tissue responses that are comparable to poly( p -dioxanone). In addition, the copolymers were found to degrade hydrolytically at controlled rates over a period of several months under physiological conditions. The poly(PDL- co -DO) copolymers with up to 69 mol% DO units were successfully transformed to free-standing nanoparticles that are capable of encapsulating an anticancer drug, doxorubicin, or a polynucleotide, siRNA. Drug- or siRNA-loaded nanoparticles exhibited controlled and continuous release of agent over many weeks. In addition, siLUC-encapsulated poly(PDL- co -DO) nanoparticles were active in inhibiting luciferase gene expression in LUC-RKO cells. Because of substantial differences in structure and hydrophobicity between PDL and DO units, poly(PDL- co -DO) biodegradation rate and physical properties can be tuned over a wide range depending on the copolymer composition. Our results demonstrate that the semicrystalline and biodegradable poly(PDL- co -DO) copolyesters are promising biomaterials to serve as drug carriers, as well as potential raw materials for constructing bioabsorbable sutures and other medical devices.
Editor: Netherlands: Elsevier Ltd
Idioma: Inglês

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Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone- co - p -dioxanone) copolyesters

Liu, Jie ; Jiang, Zhaozhong ; Zhang, Shengmin ; Liu, Chen ; Gross, Richard A ; Kyriakides, Themis R ; Saltzman, W. Mark

Netherlands: Elsevier Ltd

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