Idioma:

Treatment outcome in older patients with childhood acute myeloid leukemia

Rubnitz, Jeffrey E. ; Pounds, Stanley ; Cao, Xueyuan ; Jenkins, Laura ; Dahl, Gary ; Bowman, W. Paul ; Taub, Jeffrey W ; Pui, Ching‐Hon ; Ribeiro, Raul C. ; Campana, Dario ; Inaba, Hiroto

Cancer, 2012-12, Vol.118 (24), p.6253-6259 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Texto completo disponível

Citações Citado por

Enviar para

Título:
Treatment outcome in older patients with childhood acute myeloid leukemia
Autor: Rubnitz, Jeffrey E. ; Pounds, Stanley ; Cao, Xueyuan ; Jenkins, Laura ; Dahl, Gary ; Bowman, W. Paul ; Taub, Jeffrey W ; Pui, Ching‐Hon ; Ribeiro, Raul C. ; Campana, Dario ; Inaba, Hiroto
Assuntos: acute myeloid leukemia ; Adolescent ; adolescents ; Adult ; age ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Cladribine - administration & dosage ; Combined Modality Therapy ; Cytarabine - administration & dosage ; Etoposide - administration & dosage ; Female ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute - mortality ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; pediatrics ; Prognosis ; Survival Rate ; Transplantation, Autologous ; Tumors ; Young Adult
É parte de: Cancer, 2012-12, Vol.118 (24), p.6253-6259
Notas: Fax: (901) 521‐9005
Descrição: BACKGROUND. Older age has historically been an adverse prognostic factor in pediatric acute myeloid leukemia (AML). To the authors' knowledge, the impact of age relative to that of other prognostic factors on the outcome of patients treated in recent trials is unknown. METHODS. Clinical outcome and causes of treatment failure of 351 patients enrolled on 3 consecutive protocols for childhood AML between 1991 and 2008 were analyzed according to age and protocol. RESULTS. The more recent protocol (AML02) produced improved outcomes for patients aged 10 years to 21 years compared with 2 earlier studies (AML91 and AML97), with 3‐year rates of event‐free survival (EFS), overall survival (OS), and cumulative incidence of refractory leukemia or recurrence (CIR) for this group being similar to those of patients aged birth to 9 years: EFS: 58.3% ± 5.4% versus 66.6% ± 4.9% (P = .20); OS: 68.9% ± 5.1% versus 75.1% ± 4.5% (P = .36); and CIR: 21.9% ± 4.4% versus 25.3% ± 4.2% (P = .59). The EFS and OS estimates for patients aged 10 to 15 years overlapped those for patients aged 16 to 21 years. However, the cumulative incidence of toxic death was significantly higher for patients aged 10 to 21 years compared with younger patients (13.2% ± 3.6% vs 4.5% ± 2.0%; P = .028). CONCLUSIONS. The survival rate for older children with AML has improved on the results of a recent trial and is now similar to that of younger patients. However, deaths from toxicity remain a significant problem for patients in the older age group. Future trials should focus on improving supportive care while striving to develop more effective antileukemic therapy. Cancer 2012. © 2012 American Cancer Society. In recent trials, outcomes have improved for children and adolescents with acute myeloid leukemia. However, treatment‐related mortality remains significantly higher for adolescents compared with younger patients.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês;Alemão

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Treatment outcome in older patients with childhood acute myeloid leukemia

Rubnitz, Jeffrey E. ; Pounds, Stanley ; Cao, Xueyuan ; Jenkins, Laura ; Dahl, Gary ; Bowman, W. Paul ; Taub, Jeffrey W ; Pui, Ching‐Hon ; Ribeiro, Raul C. ; Campana, Dario ; Inaba, Hiroto

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Buscando em bases de dados remotas. Favor aguardar.