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Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer

Jia, Wei-Hua ; Zhang, Ben ; Matsuo, Keitaro ; Shin, Aesun ; Xiang, Yong-Bing ; Jee, Sun Ha ; Kim, Dong-Hyun ; Ren, Zefang ; Cai, Qiuyin ; Long, Jirong ; Shi, Jiajun ; Wen, Wanqing ; Yang, Gong ; Delahanty, Ryan J ; Ji, Bu-Tian ; Pan, Zhi-Zhong ; Matsuda, Fumihiko ; Gao, Yu-Tang ; Oh, Jae Hwan ; Ahn, Yoon-Ok ; Park, Eun Jung ; Li, Hong-Lan ; Park, Ji Won ; Jo, Jaeseong ; Jeong, Jin-Young ; Hosono, Satoyo ; Casey, Graham ; Peters, Ulrike ; Shu, Xiao-Ou ; Zeng, Yi-Xin ; Zheng, Wei

Nature genetics, 2013-02, Vol.45 (2), p.191-196 [Periódico revisado por pares]

United States: Nature Publishing Group

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Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
Autor: Jia, Wei-Hua ; Zhang, Ben ; Matsuo, Keitaro ; Shin, Aesun ; Xiang, Yong-Bing ; Jee, Sun Ha ; Kim, Dong-Hyun ; Ren, Zefang ; Cai, Qiuyin ; Long, Jirong ; Shi, Jiajun ; Wen, Wanqing ; Yang, Gong ; Delahanty, Ryan J ; Ji, Bu-Tian ; Pan, Zhi-Zhong ; Matsuda, Fumihiko ; Gao, Yu-Tang ; Oh, Jae Hwan ; Ahn, Yoon-Ok ; Park, Eun Jung ; Li, Hong-Lan ; Park, Ji Won ; Jo, Jaeseong ; Jeong, Jin-Young ; Hosono, Satoyo ; Casey, Graham ; Peters, Ulrike ; Shu, Xiao-Ou ; Zeng, Yi-Xin ; Zheng, Wei
Assuntos: Asian Continental Ancestry Group - genetics ; Chromosomes, Human, Pair 12 - genetics ; Chromosomes, Human, Pair 20 - genetics ; Chromosomes, Human, Pair 5 - genetics ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Cyclin D2 - genetics ; Development and progression ; European Continental Ancestry Group - genetics ; Far East ; Genealogy ; Genetic aspects ; Genetic Predisposition to Disease - genetics ; Genetic susceptibility ; Genetics ; Genetics, Population ; Genome, Human - genetics ; Genome-Wide Association Study ; Genomes ; Genotype ; Humans ; Medical research ; Odds Ratio ; Polymorphism, Single Nucleotide - genetics ; Principal Component Analysis ; Risk factors ; Studies
É parte de: Nature genetics, 2013-02, Vol.45 (2), p.191-196
Notas: ObjectType-Article-1
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These authors jointly directed this work.
These authors contributed equally to this work.
A complete list of investigators in GECCO (Genetics and Epidemiology of Colorectal Cancer Consortium) and CCFR (Colon Cancer Family Registry) is provided in the Acknowledgement section.
Descrição: To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10(-7) to 3.77 × 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10(-10) for rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279 (20p12.3) and 3.06 × 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer

United States: Nature Publishing Group

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