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Opiate versus psychostimulant addiction: the differences do matter

Badiani, Aldo ; Shaham, Yavin ; Belin, David ; Epstein, David ; Calu, Donna

Nature reviews. Neuroscience, 2011-11, Vol.12 (11), p.685-700 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Opiate versus psychostimulant addiction: the differences do matter
Autor: Badiani, Aldo ; Shaham, Yavin ; Belin, David ; Epstein, David ; Calu, Donna
Assuntos: Abstinence ; Amphetamine-Related Disorders - physiopathology ; Amphetamine-Related Disorders - psychology ; Amphetamines ; Animal cognition ; Animals ; Behavior, Addictive - physiopathology ; Behavior, Addictive - psychology ; Brain - physiopathology ; Care and treatment ; Cocaine ; Cocaine-Related Disorders - physiopathology ; Cocaine-Related Disorders - psychology ; Dopamine ; Drug abuse ; Drug addiction ; Drug use ; Drug withdrawal ; Flexibility ; Gene expression ; Genetic aspects ; Health aspects ; Heroin ; Humans ; Impulsivity ; Laboratory animals ; Morphine ; Narcotics ; Neurobiology ; Opioid-Related Disorders - physiopathology ; Opioid-Related Disorders - psychology ; Psychobiology ; Reward
É parte de: Nature reviews. Neuroscience, 2011-11, Vol.12 (11), p.685-700
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction - hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction - all argue for a unitary account of drug addiction. This view is challenged by behavioural, cognitive and neurobiological findings in laboratory animals and humans. Here, we argue that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Opiate versus psychostimulant addiction: the differences do matter

Badiani, Aldo ; Shaham, Yavin ; Belin, David ; Epstein, David ; Calu, Donna

England: Nature Publishing Group

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