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Risk of macular degeneration in users of statins: cross sectional study

Hall, Nigel F ; Gale, Catharine R ; Syddall, Holly ; Phillips, David I W ; Martyn, Christopher N

BMJ, 2001-08, Vol.323 (7309), p.375-376 [Periódico revisado por pares]

London: British Medical Journal Publishing Group

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Título:
Risk of macular degeneration in users of statins: cross sectional study
Autor: Hall, Nigel F ; Gale, Catharine R ; Syddall, Holly ; Phillips, David I W ; Martyn, Christopher N
Assuntos: Age ; Aged ; Alzheimer's disease ; Biological and medical sciences ; Cardiovascular disease ; Confidence intervals ; Coronary Angiography ; Coronary Artery Bypass ; Coronary Disease - complications ; Coronary Disease - drug therapy ; Coronary Disease - surgery ; Coronary vessels ; Cross-Sectional Studies ; Disease risk ; Drug therapy ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Logistic Models ; Macular degeneration ; Macular Degeneration - complications ; Macular Degeneration - prevention & control ; Male ; Medical sciences ; Percutaneous transluminal coronary angioplasty ; Pharmacology. Drug treatments ; Risk ; Side effects ; Smoking - adverse effects ; Statins ; Toxicity: eye ; Women
É parte de: BMJ, 2001-08, Vol.323 (7309), p.375-376
Notas: istex:710C728420F8C0669F18136A6D46B4262E1495EA
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Correspondence to: C N Martyn
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Contributors: NFH, CRG, DIWP, and CNM formulated the design of the study. NFH and CRG carried out the fieldwork. HS analysed the data. The paper was written by NFH and CNM, and edited by CNM, CRG, and DIWP. NFH and CNM are guarantors for the paper.
Correspondence to: C N Martyn cnm@mrc.soton.ac.uk
Descrição: Atherosclerosis and abnormalities of lipid metabolism are associated with an increased risk of age related macular degeneration-the Western world's main cause of blindness. 1 Statins (hydroxymethyl glutaryl coenzyme A reductase inhibitors) modify patients' lipid profile and lower their risk of coronary heart disease. 2 They also prevent stroke and, possibly, Alzheimer's disease. [...]statins might prevent the accumulation of basal linear deposit in Bruch's membrane, which occurs with higher concentrations of plasma cholesterol. 4 Secondly, antioxidant properties of statins might protect the outer retina from oxidative damage.
Editor: London: British Medical Journal Publishing Group
Idioma: Inglês

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Risk of macular degeneration in users of statins: cross sectional study

Hall, Nigel F ; Gale, Catharine R ; Syddall, Holly ; Phillips, David I W ; Martyn, Christopher N

London: British Medical Journal Publishing Group

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