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Modeling the within-host dynamics of HIV infection

Perelson, Alan S ; Ribeiro, Ruy M

BMC biology, 2013-09, Vol.11 (1), p.96-96, Article 96 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Modeling the within-host dynamics of HIV infection
Autor: Perelson, Alan S ; Ribeiro, Ruy M
Assuntos: Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; BASIC BIOLOGICAL SCIENCES ; Drug Resistance, Viral ; Drug therapy ; Epidemiology ; Highly active antiretroviral therapy ; HIV ; HIV infection ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 - immunology ; HIV-1 - metabolism ; Host-Pathogen Interactions ; Human immunodeficiency virus ; Humans ; Immune response ; Immune system ; Infections ; Life Sciences & Biomedicine - Other Topics ; Medical research ; Medicine, Experimental ; Microbiology ; Models, Biological ; Molecular biology ; Numerical analysis ; Physiological aspects ; Review ; T cells ; T-Lymphocytes, Cytotoxic - immunology ; Virus diseases
É parte de: BMC biology, 2013-09, Vol.11 (1), p.96-96, Article 96
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
AC52-06NA25396
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Descrição: The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, the response to drug therapy and the rate of generation of HIV variants that escape immune responses. We show how modeling has revealed many dynamical features of HIV infection and how it may provide insight into the ultimate cure for this infection.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Modeling the within-host dynamics of HIV infection

Perelson, Alan S ; Ribeiro, Ruy M

England: BioMed Central Ltd

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