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Emergency presentation of cancer and short-term mortality

MCPHAIL, S ; ELLISS-BROOKES, L ; SHELTON, J ; IVES, A ; GREENSLADE, M ; VERNON, S ; MORRIS, E. J. A ; RICHARDS, M

British journal of cancer, 2013-10, Vol.109 (8), p.2027-2034 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
Emergency presentation of cancer and short-term mortality
Autor: MCPHAIL, S ; ELLISS-BROOKES, L ; SHELTON, J ; IVES, A ; GREENSLADE, M ; VERNON, S ; MORRIS, E. J. A ; RICHARDS, M
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Breast Neoplasms - diagnosis ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Child ; Child, Preschool ; Clinical Study ; Colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Emergencies - epidemiology ; England - epidemiology ; Female ; Humans ; Infant ; Lung Neoplasms - diagnosis ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Models, Statistical ; Morbidity ; Mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Staging ; Neoplasms - diagnosis ; Neoplasms - mortality ; Neoplasms - pathology ; Prostate ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Public health ; Registration ; Skin cancer ; Tumors ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - pathology ; Young Adult
É parte de: British journal of cancer, 2013-10, Vol.109 (8), p.2027-2034
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The short-term survival following a cancer diagnosis in England is lower than that in comparable countries, with the difference in excess mortality primarily occurring in the months immediately after diagnosis. We assess the impact of emergency presentation (EP) on the excess mortality in England over the course of the year following diagnosis. All colorectal and cervical cancers presenting in England and all breast, lung, and prostate cancers in the East of England in 2006-2008 are included. The variation in the likelihood of EP with age, stage, sex, co-morbidity, and income deprivation is modelled. The excess mortality over 0-1, 1-3, 3-6, and 6-12 months after diagnosis and its dependence on these case-mix factors and presentation route is then examined. More advanced stage and older age are predictive of EP, as to a lesser extent are co-morbidity, higher income deprivation, and female sex. In the first month after diagnosis, we observe case-mix-adjusted excess mortality rate ratios of 7.5 (cervical), 5.9 (colorectal), 11.7 (breast ), 4.0 (lung), and 20.8 (prostate) for EP compared with non-EP. Individuals who present as an emergency experience high short-term mortality in all cancer types examined compared with non-EPs. This is partly a case-mix effect but EP remains predictive of short-term mortality even when age, stage, and co-morbidity are accounted for.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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Emergency presentation of cancer and short-term mortality

MCPHAIL, S ; ELLISS-BROOKES, L ; SHELTON, J ; IVES, A ; GREENSLADE, M ; VERNON, S ; MORRIS, E. J. A ; RICHARDS, M

Basingstoke: Nature Publishing Group

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