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Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity

Skinner, Michael K ; Manikkam, Mohan ; Tracey, Rebecca ; Guerrero-Bosagna, Carlos ; Haque, Muksitul ; Nilsson, Eric E

BMC medicine, 2013-10, Vol.11 (1), p.228-228, Article 228 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
Autor: Skinner, Michael K ; Manikkam, Mohan ; Tracey, Rebecca ; Guerrero-Bosagna, Carlos ; Haque, Muksitul ; Nilsson, Eric E
Assuntos: Animals ; Chromosomes - drug effects ; DDT ; DDT (Insecticide) ; DDT - toxicity ; Development and progression ; DNA Methylation - drug effects ; Environmental aspects ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Female ; Gene Regulatory Networks - drug effects ; Genetic aspects ; Health aspects ; Humans ; Kidney diseases ; Malaria ; Male ; Maternal Exposure ; Medical research ; Medicine, Experimental ; Methylation ; Mutation ; Obesity ; Obesity - chemically induced ; Obesity - genetics ; Rats ; Rats, Sprague-Dawley ; Spermatozoa - drug effects ; Studies ; Type 2 diabetes
É parte de: BMC medicine, 2013-10, Vol.11 (1), p.228-228, Article 228
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on obesity and associated disease. Outbred gestating female rats were transiently exposed to a vehicle control or DDT and the F1 generation offspring bred to generate the F2 generation and F2 generation bred to generate the F3 generation. The F1 and F3 generation control and DDT lineage rats were aged and various pathologies investigated. The F3 generation male sperm were collected to investigate methylation between the control and DDT lineage male sperm. The F1 generation offspring (directly exposed as a fetus) derived from the F0 generation exposed gestating female rats were not found to develop obesity. The F1 generation DDT lineage animals did develop kidney disease, prostate disease, ovary disease and tumor development as adults. Interestingly, the F3 generation (great grand-offspring) had over 50% of males and females develop obesity. Several transgenerational diseases previously shown to be associated with metabolic syndrome and obesity were observed in the testis, ovary and kidney. The transgenerational transmission of disease was through both female (egg) and male (sperm) germlines. F3 generation sperm epimutations, differential DNA methylation regions (DMR), induced by DDT were identified. A number of the genes associated with the DMR have previously been shown to be associated with obesity. Observations indicate ancestral exposure to DDT can promote obesity and associated disease transgenerationally. The etiology of disease such as obesity may be in part due to environmentally induced epigenetic transgenerational inheritance.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity

Skinner, Michael K ; Manikkam, Mohan ; Tracey, Rebecca ; Guerrero-Bosagna, Carlos ; Haque, Muksitul ; Nilsson, Eric E

England: BioMed Central Ltd

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