Idioma:

Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

Jia, Zhiyun, MD, PhD ; Wang, Yuqing, PhD ; Huang, Xiaoqi, PhD ; Wu, Qizhu, PhD ; Lui, Su, MD, PhD ; Gong, Qiyong, MD, PhD ; Kuang, Weihong, MD ; Sweeney, John A., PhD

Journal of psychiatry & neuroscience, 2014-05, Vol.39 (3), p.170-177 [Periódico revisado por pares]

Ottawa, ON: Canadian Medical Association

Texto completo disponível

Citações Citado por

Enviar para

Título:
Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T
Autor: Jia, Zhiyun, MD, PhD ; Wang, Yuqing, PhD ; Huang, Xiaoqi, PhD ; Wu, Qizhu, PhD ; Lui, Su, MD, PhD ; Gong, Qiyong, MD, PhD ; Kuang, Weihong, MD ; Sweeney, John A., PhD
Assuntos: Adult ; Adult and adolescent clinical studies ; Behavior ; Biological and medical sciences ; Brain mapping ; Brain research ; Cognition ; Depressive Disorder, Major - pathology ; Diffusion Tensor Imaging ; Female ; Frontal Lobe - pathology ; Fundamental and applied biological sciences. Psychology ; Head injuries ; Hospitals ; Humans ; Internal Capsule - pathology ; Male ; Medical Education ; Medical sciences ; Mental depression ; Neurosciences ; Psychiatry ; Psychoanalysis ; Psychological aspects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Papers ; Studies ; Suicidal behavior ; Suicide ; Suicide, Attempted ; Suicides & suicide attempts ; Thalamus - pathology
É parte de: Journal of psychiatry & neuroscience, 2014-05, Vol.39 (3), p.170-177
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
Descrição: Background The neurobiology of suicide is largely unknown. Studies of white matter tracts in patients with a history of suicidal behaviour have shown alteration in the left anterior limb of the internal capsule (ALIC). Our aim was to determine whether particular target fields of fibre projections through the ALIC are affected in depressed patients who recently attempted suicide. Methods We studied patients with major depressive disorder (MDD) with and without a history of suicide attempts and healthy controls using diffusion tensor imaging (DTI) and deterministic tractography to generate fibre tract maps for each participant. Tract voxels were coded as being unique to the left ALIC. We compared the mean percentage of fibres projecting to relevant brain regions in the 3 groups using analysis of covariance. Results We included 63 patients with MDD (23 with and 40 without a history of suicide attempts) and 46 controls in our study. Both groups of depressed patients had reduced fibre projections through the ALIC to the left medial frontal cortex, orbitofrontal cortex and thalamus. Those with a history of suicide attempts had greater abnormalities than those without suicide attempts in the left orbitofrontal cortex and thalamus. Limitations Diffusion tensor imaging deterministic tracking is unable to distinguish between afferent and efferent pathways, limiting our ability to distinguish the directionality of altered fibre tracts. Conclusion Frontothalamic loops passing through the ALIC are abnormal in patients with depression and significantly more abnormal in depressed patients with a history of suicide attempts than in those without a history of suicide attempts. Abnormal projections to the orbitofrontal cortex and thalamus may disrupt affective and cognitive functions to confer a heightened vulnerability for suicidal behaviour.
Editor: Ottawa, ON: Canadian Medical Association
Idioma: Francês;Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

Jia, Zhiyun, MD, PhD ; Wang, Yuqing, PhD ; Huang, Xiaoqi, PhD ; Wu, Qizhu, PhD ; Lui, Su, MD, PhD ; Gong, Qiyong, MD, PhD ; Kuang, Weihong, MD ; Sweeney, John A., PhD

Ottawa, ON: Canadian Medical Association

Buscando em bases de dados remotas. Favor aguardar.