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Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum

Omonijo, Oluwaseyi ; Wongprayoon, Pawaris ; Ladenheim, Bruce ; McCoy, Michael T. ; Govitrapong, Piyarat ; Jayanthi, Subramaniam ; Cadet, Jean Lud

Neurotoxicology (Park Forest South), 2014-12, Vol.45, p.178-184 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum
Autor: Omonijo, Oluwaseyi ; Wongprayoon, Pawaris ; Ladenheim, Bruce ; McCoy, Michael T. ; Govitrapong, Piyarat ; Jayanthi, Subramaniam ; Cadet, Jean Lud
Assuntos: Animals ; Biological and medical sciences ; Epigenetics ; Gene expression ; Histone Deacetylases - metabolism ; Male ; Medical sciences ; Methamphetamine - administration & dosage ; Methamphetamine - toxicity ; Mitochondrial Proteins - drug effects ; Mitochondrial Proteins - metabolism ; Neostriatum - drug effects ; Neostriatum - metabolism ; Neuropharmacology ; Neurotoxicity ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Sirtuins ; Sirtuins - metabolism ; Toxicology
É parte de: Neurotoxicology (Park Forest South), 2014-12, Vol.45, p.178-184
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: •Methamphetamine (METH) is an addictive and toxic agent.•Toxic doses of METH cause significant decreased HDAC6, 8, 9, 10 and 11 mRNA levels in the rat striatum.•METH also decreases the expression of the mitochondrial HDAC, SIRT5.•In addition, the expression of the nuclear HDACs, SIRT2 and SIRT6, is also decreased by the METH injections.•The present observations add to the accumulating evidence that METH can substantially influence epigenetic landscapes in the brain. Methamphetamine use disorder is characterized by recurrent binge episodes. Humans addicted to methamphetamine experience various degrees of cognitive deficits and show evidence of neurodegenerative processes in the brain. Binge injections of METH to rodents also cause significant toxic changes in the brain. In addition, this pattern of METH injections can alter gene expression in the dorsal striatum. Gene expression is regulated, in part, by histone deacetylation. We thus tested the possibility that METH toxic doses might cause changes in the mRNA levels of histone deacetylases (HDACs). We found that METH did produce significant decreases in the mRNA expression of HDAC8, which is a class I HDAC. METH also decreased expression of HDAC6, HDAC9, and HDAC10 that are class II HDACs. The expression of the class IV HDAC, HDAC11, was also suppressed by METH. The expression of Sirt2, Sirt5, and Sirt6 that are members of class III HDACs was also downregulated by METH injections. Our findings implicate changes in HDAC expression may be an early indicator of impending METH-induced neurotoxicity in the striatum. This idea is consistent with the accumulated evidence that some HDACs are involved in neurodegenerative processes in the brain.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum

Omonijo, Oluwaseyi ; Wongprayoon, Pawaris ; Ladenheim, Bruce ; McCoy, Michael T. ; Govitrapong, Piyarat ; Jayanthi, Subramaniam ; Cadet, Jean Lud

Amsterdam: Elsevier B.V

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