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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, Xintian ; Vlatkovic, Irena ; Babic, Ana ; Will, Tristan ; Epstein, Irina ; Tushev, Georgi ; Akbalik, Güney ; Wang, Mantian ; Glock, Caspar ; Quedenau, Claudia ; Wang, Xi ; Hou, Jingyi ; Liu, Hongyu ; Sun, Wei ; Sambandan, Sivakumar ; Chen, Tao ; Schuman, Erin M ; Chen, Wei

Nature neuroscience, 2015-04, Vol.18 (4), p.603-610 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Autor: You, Xintian ; Vlatkovic, Irena ; Babic, Ana ; Will, Tristan ; Epstein, Irina ; Tushev, Georgi ; Akbalik, Güney ; Wang, Mantian ; Glock, Caspar ; Quedenau, Claudia ; Wang, Xi ; Hou, Jingyi ; Liu, Hongyu ; Sun, Wei ; Sambandan, Sivakumar ; Chen, Tao ; Schuman, Erin M ; Chen, Wei
Assuntos: Animals ; Brain - growth & development ; Brain - metabolism ; Brain mapping ; Brain research ; Dendrites - metabolism ; Female ; Genes ; Genetic aspects ; Genomes ; Hippocampus - metabolism ; In Situ Hybridization ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs ; Neural transmission ; Neuronal Plasticity - physiology ; Neuropil - metabolism ; Patch-Clamp Techniques ; Properties ; Proteins ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA - metabolism ; RNA, Circular ; Sequence Analysis, RNA ; Synapses - genetics
É parte de: Nature neuroscience, 2015-04, Vol.18 (4), p.603-610
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Author contributions. X.Y. and G.T. designed and performed all bioinformatic analysis and edited the manuscript. I.V.,A.B., T.W., I.E. and G.A. designed, conducted ,analyzed the experiments, with the help of M.W, C.G, C.Q., X.W., J.H., H.L., W.S.,,and edited the manuscript. SS performed and analysed electrophysiology experiments. W.C. and E.M.S. conceived and supervised the project, wrote the manuscript.
Descrição: Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep RNA profiling in different mouse tissues, we observed that circRNAs were substantially enriched in brain and a disproportionate fraction of them were derived from host genes that encode synaptic proteins. Moreover, on the basis of separate profiling of the RNAs localized in neuronal cell bodies and neuropil, circRNAs were, on average, more enriched in the neuropil than their host gene mRNA isoforms. Using high-resolution in situ hybridization, we visualized circRNA punctae in the dendrites of neurons. Consistent with the idea that circRNAs might regulate synaptic function during development, many circRNAs changed their abundance abruptly at a time corresponding to synaptogenesis. In addition, following a homeostatic downscaling of neuronal activity many circRNAs exhibited substantial up- or downregulation. Together, our data indicate that brain circRNAs are positioned to respond to and regulate synaptic function.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, Xintian ; Vlatkovic, Irena ; Babic, Ana ; Will, Tristan ; Epstein, Irina ; Tushev, Georgi ; Akbalik, Güney ; Wang, Mantian ; Glock, Caspar ; Quedenau, Claudia ; Wang, Xi ; Hou, Jingyi ; Liu, Hongyu ; Sun, Wei ; Sambandan, Sivakumar ; Chen, Tao ; Schuman, Erin M ; Chen, Wei

United States: Nature Publishing Group

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