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Body mass index at 11 years and bone mass at age 18: path analysis within the 1993 Pelotas (Brazil) birth cohort study

Muniz, Ludmila Correa ; Menezes, Ana Maria Baptista ; Assunção, Maria Cecília Formoso ; Martínez-Mesa, Jeovany ; Wehrmeister, Fernando Cesar ; Howe, Laura D ; Hallal, Pedro Curi ; Gonçalves, Helen ; Barros, Fernando C

BMC musculoskeletal disorders, 2015-03, Vol.16 (1), p.71-71, Article 71 [Periódico revisado por pares]

England: BioMed Central Ltd

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Body mass index at 11 years and bone mass at age 18: path analysis within the 1993 Pelotas (Brazil) birth cohort study
Autor: Muniz, Ludmila Correa ; Menezes, Ana Maria Baptista ; Assunção, Maria Cecília Formoso ; Martínez-Mesa, Jeovany ; Wehrmeister, Fernando Cesar ; Howe, Laura D ; Hallal, Pedro Curi ; Gonçalves, Helen ; Barros, Fernando C
Assuntos: Absorptiometry, Photon ; Adipose Tissue - physiology ; Adolescent ; Analysis ; Body Composition - physiology ; Body Mass Index ; Bone Density - physiology ; Bones ; Brazil ; Child ; Cohort Studies ; Density ; Female ; Health aspects ; Humans ; Longitudinal Studies ; Male ; Mediation ; Physiological aspects ; Plethysmography ; Prospective Studies ; Retrospective Studies ; Sex Factors
É parte de: BMC musculoskeletal disorders, 2015-03, Vol.16 (1), p.71-71, Article 71
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We investigated whether Body Mass Index (BMI) at 11 years old has a direct effect on bone mass at age 18 operating through alterations to bone growth and development, or whether the association is mediated by concurrent BMI, fat mass (FM), and fat free mass (FFM). Path analysis was used to explore the association between BMI at age 11 and whole-body bone mineral content (BMC) and bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry (DXA) at age 18 in a prospective birth cohort study comprising 3,307 adolescents; we also evaluated the degree to which this association was mediated by BMI, FM (kg) and FFM (kg) assessed by plethysmography (BOD POD) at age 18. We found a positive association between BMI at age 11 and BMC (males [β = 179.7 g, 95% CI 161.4; 198.0]; females [β = 179.9 g, 95% CI 165.3; 194.6]) and BMD (males [β = 0.030 g/cm2, 95% CI 0.024; 0.035]; females [β = 0.029 g/cm2, 95% CI 0.025; 0.033]) at age 18. This association was largely mediated by BMI and FFM at age 18 in both female and male adolescents. FM at age 18 was not an important mediator. Concurrent BMI and FFM were the main mediators of the association between BMC/BMD in late adolescence and BMI in early adolescence.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Body mass index at 11 years and bone mass at age 18: path analysis within the 1993 Pelotas (Brazil) birth cohort study

Muniz, Ludmila Correa ; Menezes, Ana Maria Baptista ; Assunção, Maria Cecília Formoso ; Martínez-Mesa, Jeovany ; Wehrmeister, Fernando Cesar ; Howe, Laura D ; Hallal, Pedro Curi ; Gonçalves, Helen ; Barros, Fernando C

England: BioMed Central Ltd

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