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High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial

Raja-Khan, Nazia, M.D ; Shah, Julie, M.D ; Stetter, Christy M., B.S ; Lott, Mary E.J., Ph.D ; Kunselman, Allen R., M.A ; Dodson, William C., M.D ; Legro, Richard S., M.D

Fertility and sterility, 2014-06, Vol.101 (6), p.1740-1746 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial
Autor: Raja-Khan, Nazia, M.D ; Shah, Julie, M.D ; Stetter, Christy M., B.S ; Lott, Mary E.J., Ph.D ; Kunselman, Allen R., M.A ; Dodson, William C., M.D ; Legro, Richard S., M.D
Assuntos: Academic Medical Centers ; Adolescent ; Adult ; Biomarkers - blood ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; blood pressure ; Blood Pressure - drug effects ; Cholecalciferol - administration & dosage ; Dietary Supplements ; Double-Blind Method ; Female ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Insulin Resistance ; Internal Medicine ; Middle Aged ; Obstetrics and Gynecology ; Pennsylvania ; Pilot Projects ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnosis ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - physiopathology ; Time Factors ; Treatment Outcome ; vitamin D ; Vitamins - administration & dosage ; Young Adult
É parte de: Fertility and sterility, 2014-06, Vol.101 (6), p.1740-1746
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: Objective To determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS). Design Randomized, placebo-controlled trial. Setting Academic medical center. Patient(s) Twenty-eight women with PCOS. Intervention(s) Vitamin D3, 12,000 IU, or placebo daily for 12 weeks. Main Outcome Measure(s) The primary outcome was quantitative insulin sensitivity check index. Secondary outcomes included glucose and insulin levels during a 75-g oral glucose tolerance test and blood pressure. Result(s) Twenty-two women completed the study. Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to 79.2] ng/mL at 12 weeks; placebo 22.5 [18.1 to 26.8] ng/mL at baseline and 23.8 [10.4 to 37.2] ng/mL at 12 weeks). There were no significant differences in quantitative insulin sensitivity check index and other measures of insulin sensitivity; however, we observed trends toward lower 2-hour insulin and lower 2-hour glucose. We also observed a protective effect of vitamin D on blood pressure. Conclusion(s) In women with PCOS, insulin sensitivity was unchanged with high-dose vitamin D, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure. Clinical Trial Registration Number NCT00907153.
Editor: United States: Elsevier Inc
Idioma: Inglês

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High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial

Raja-Khan, Nazia, M.D ; Shah, Julie, M.D ; Stetter, Christy M., B.S ; Lott, Mary E.J., Ph.D ; Kunselman, Allen R., M.A ; Dodson, William C., M.D ; Legro, Richard S., M.D

United States: Elsevier Inc

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