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18F-fluorodeoxyglucose Positron Emission Tomography in Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease: Correlation With Activity, Severity, Inflammatory and Virologic Parameters

Polizzotto, Mark N ; Millo, Corina ; Uldrick, Thomas S ; Aleman, Karen ; Whatley, Millie ; Wyvill, Kathleen M ; O'Mahony, Deirdre ; Marshall, Vickie ; Whitby, Denise ; Maass-Moreno, Roberto ; Steinberg, Seth M ; Little, Richard F ; Yarchoan, Robert

The Journal of infectious diseases, 2015-10, Vol.212 (8), p.1250-1260 [Periódico revisado por pares]

United States: Oxford University Press

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18F-fluorodeoxyglucose Positron Emission Tomography in Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease: Correlation With Activity, Severity, Inflammatory and Virologic Parameters
Autor: Polizzotto, Mark N ; Millo, Corina ; Uldrick, Thomas S ; Aleman, Karen ; Whatley, Millie ; Wyvill, Kathleen M ; O'Mahony, Deirdre ; Marshall, Vickie ; Whitby, Denise ; Maass-Moreno, Roberto ; Steinberg, Seth M ; Little, Richard F ; Yarchoan, Robert
Assuntos: Adult ; C-Reactive Protein - metabolism ; Castleman Disease - complications ; Castleman Disease - diagnostic imaging ; Castleman Disease - virology ; Female ; Fluorine Radioisotopes - analysis ; Fluorodeoxyglucose F18 ; Herpesvirus 8, Human - physiology ; HIV Infections - complications ; Humans ; Lymph Nodes - diagnostic imaging ; Major and Brief Reports ; Male ; Middle Aged ; Positron-Emission Tomography - methods ; Prospective Studies ; Salivary Glands - diagnostic imaging ; Sarcoma, Kaposi - complications ; Sarcoma, Kaposi - diagnostic imaging ; Sarcoma, Kaposi - virology ; Spleen - diagnostic imaging
É parte de: The Journal of infectious diseases, 2015-10, Vol.212 (8), p.1250-1260
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Kaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease (MCD) is a lymphoproliferative inflammatory disorder commonly associated with human immunodeficiency virus (HIV). Its presentation may be difficult to distinguish from HIV and its complications, including lymphoma. Novel imaging strategies could address these problems. We prospectively characterized (18)F-fluorodeoxyglucose positron emission tomography (PET) findings in 27 patients with KSHV-MCD. Patients were imaged with disease activity and at remission with scans evaluated blind to clinical status. Symptoms, C-reactive protein level, and HIV and KSHV loads were assessed in relation to imaging findings. KSHV-MCD activity was associated with hypermetabolic symmetric lymphadenopathy (median maximal standardized uptake value [SUVmax], 6.0; range, 2.0-8.0) and splenomegaly (3.4; 1.2-11.0), with increased metabolism also noted in the marrow (2.1; range, 1.0-3.5) and salivary glands (3.0; range, 2.0-6.0). The (18)F-fluorodeoxyglucose PET abnormalities improved at remission, with significant SUVmax decreases in the lymph nodes (P = .004), spleen (P = .008), marrow (P = .004), and salivary glands (P = .004). Nodal SUVmax correlated with symptom severity (P = .005), C-reactive protein level (R = 0.62; P = .004), and KSHV load (R = 0.54; P = .02) but not HIV load (P = .52). KSHV-MCD activity is associated with (18)F-FDG PET abnormalities of the lymph nodes, spleen, marrow, and salivary glands. These findings have clinical implications for the diagnosis and monitoring of KSHV-MCD and shed light on its pathobiologic mechanism.
Editor: United States: Oxford University Press
Idioma: Inglês

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18F-fluorodeoxyglucose Positron Emission Tomography in Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease: Correlation With Activity, Severity, Inflammatory and Virologic Parameters

Polizzotto, Mark N ; Millo, Corina ; Uldrick, Thomas S ; Aleman, Karen ; Whatley, Millie ; Wyvill, Kathleen M ; O'Mahony, Deirdre ; Marshall, Vickie ; Whitby, Denise ; Maass-Moreno, Roberto ; Steinberg, Seth M ; Little, Richard F ; Yarchoan, Robert

United States: Oxford University Press

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