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Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye

Choi, Won ; Lee, Jee Bum ; Cui, Lian ; Li, Ying ; Li, Zhengri ; Choi, Ji Suk ; Lee, Hyo Seok ; Yoon, Kyung Chul Catalá, Angel

Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.4727415-10 [Peer Reviewed Journal]

United States: Hindawi Publishing Corporation

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Title:
Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye
Author: Choi, Won ; Lee, Jee Bum ; Cui, Lian ; Li, Ying ; Li, Zhengri ; Choi, Ji Suk ; Lee, Hyo Seok ; Yoon, Kyung Chul
Catalá, Angel
Subjects: Administration, Ophthalmic ; Aldehydes - metabolism ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Antioxidants ; Antioxidants - administration & dosage ; Biomedical research ; Cytokines - metabolism ; Disease ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Experiments ; Eye - drug effects ; Eye - metabolism ; Eye - physiopathology ; Fatty acids ; Female ; Goblet Cells - drug effects ; Goblet Cells - metabolism ; Herbal medicine ; Hospitals ; Inflammation ; Inflammation Mediators - metabolism ; Light emitting diodes ; Lipid peroxidation ; Lipids ; Lymphocytes ; Medical research ; Mice, Inbred C57BL ; Ophthalmic Solutions ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Pathogenesis ; Phytotherapy ; Plant Extracts - administration & dosage ; Plants, Medicinal ; Reactive Oxygen Species - metabolism ; Rodents ; Studies ; Tears - drug effects ; Tears - metabolism ; Time Factors ; Xerophthalmia - drug therapy ; Xerophthalmia - metabolism ; Xerophthalmia - physiopathology
Is Part Of: Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.4727415-10
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Angel Catalá
Description: Purpose. To investigate the therapeutic effects of topical administration of antioxidant medicinal plant extracts in a mouse model of experimental dry eye (EDE). Methods. Eye drops containing balanced salt solution (BSS) or 0.001%, 0.01%, and 0.1% extracts were applied for the treatment of EDE. Tear volume, tear film break-up time (BUT), and corneal fluorescein staining scores were measured 10 days after desiccating stress. In addition, we evaluated the levels of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) α, IL-6, interferon- (IFN-) γ, and IFN-γ associated chemokines, percentage of CD4+C-X-C chemokine receptor type 3 positive (CXCR3+) T cells, goblet cell density, number of 4-hydroxy-2-nonenal (4-HNE) positive cells, and extracellular reactive oxygen species (ROS) production. Results. Compared to the EDE and BSS control groups, the mice treated with topical application of the 0.1% extract showed significant improvements in all clinical parameters, IL-1β, IL-6, TNF-α, and IFN-γ levels, percentage of CD4+CXCR3+ T cells, goblet cell density, number of 4-HNE-positive cells, and extracellular ROS production ( P < 0.05 ). Conclusions. Topical application of 0.1% medicinal plant extracts improved clinical signs, decreased inflammation, and ameliorated oxidative stress marker and ROS production on the ocular surface of the EDE model mice.
Publisher: United States: Hindawi Publishing Corporation
Language: English

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Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye

Choi, Won ; Lee, Jee Bum ; Cui, Lian ; Li, Ying ; Li, Zhengri ; Choi, Ji Suk ; Lee, Hyo Seok ; Yoon, Kyung Chul Catalá, Angel

United States: Hindawi Publishing Corporation

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