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Weight Loss and Lowering Androgens Predict Improvements in Health-Related Quality of Life in Women With PCOS

Dokras, Anuja ; Sarwer, David B ; Allison, Kelly C ; Milman, Lauren ; Kris-Etherton, Penny M ; Kunselman, Allen R ; Stetter, Christy M ; Williams, Nancy I ; Gnatuk, Carol L ; Estes, Stephanie J ; Fleming, Jennifer ; Coutifaris, Christos ; Legro, Richard S

The journal of clinical endocrinology and metabolism, 2016-08, Vol.101 (8), p.2966-2974 [Periódico revisado por pares]

United States: Endocrine Society

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  • Título:
    Weight Loss and Lowering Androgens Predict Improvements in Health-Related Quality of Life in Women With PCOS
  • Autor: Dokras, Anuja ; Sarwer, David B ; Allison, Kelly C ; Milman, Lauren ; Kris-Etherton, Penny M ; Kunselman, Allen R ; Stetter, Christy M ; Williams, Nancy I ; Gnatuk, Carol L ; Estes, Stephanie J ; Fleming, Jennifer ; Coutifaris, Christos ; Legro, Richard S
  • Assuntos: Adolescent ; Adult ; Androgens - blood ; Behavior Therapy ; Combined Modality Therapy ; Contraceptives, Oral - administration & dosage ; Female ; Health Status ; Humans ; Life Style ; Original ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnosis ; Polycystic Ovary Syndrome - psychology ; Polycystic Ovary Syndrome - therapy ; Preconception Care ; Prognosis ; Quality of Life ; Surveys and Questionnaires ; Treatment Outcome ; Weight Loss - physiology ; Young Adult
  • É parte de: The journal of clinical endocrinology and metabolism, 2016-08, Vol.101 (8), p.2966-2974
  • Notas: This project was supported by the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), National Center for Research Resources, and the National Center for Advancing Translational Sciences at the National Institutes of Health, through Grants R01 HD056510 (RSL), UL1 TR000127 (Penn State Clinical and Translational Institute) and U54 HD29834 (UVA Core Ligand Assay Core of the Specialized Cooperative Centers Program in Reproduction of the NICHD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH).
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  • Descrição: Context: Polycystic ovary syndrome (PCOS) is associated with reduced health-related quality of life (HRQOL) and increased prevalence of depressive and anxiety disorders. The impact of PCOS-specific treatments on these co-morbidities is unclear. Objective: To assess the impact of weight loss and decreasing hyperandrogenism on HRQOL and mood and anxiety disorders in women with PCOS. Design/Setting/Participants: A secondary analysis of a randomized controlled trial (OWL-PCOS) of preconception treatment conducted at two academic centers in women (age, 18–40 years; body mass index, 27–42 kg/m2) with PCOS defined by Rotterdam criteria. Intervention: Continuous oral contraceptive pill (OCP) or intensive lifestyle intervention or the combination (Combined) for 16 weeks. Main Outcome Measure(s): Changes in HRQOL assessed by PCOSQ and SF-36 and prevalence of depression and anxiety disorder assessed by PRIME-MD PHQ. Results: The lowest scores were noted on the general health domain of the SF-36 and the weight and infertility domains on the PCOSQ. All three interventions resulted in significant improvement in the general health score on the SF-36. Both the OCP and Combined groups showed improvements in all domains of the PCOSQ (P < .01) compared to baseline scores. The Combined group had significant improvements in the weight, body hair, and infertility domains compared to a single treatment group (P < .05). In a linear regression model, change in weight correlated with improvements in the weight domain (P < .001) and physical well-being (P < .02), change in T correlated with improvements in the hair domain (P < .001), and change in both weight and T correlated with the infertility (P < .001) and menstrual domains (P < .05). Conclusions: Both weight loss and OCP use result in significant improvements in several physical and mental domains related to quality of life, depressive symptoms, and anxiety disorders, and combined therapies offer further benefits in overweight/obese women with PCOS. Weight loss and normalization of hyperandrogenism results in improvement in health related quality of life parameters in overweight/obese women with polycystic ovary syndrome.
  • Editor: United States: Endocrine Society
  • Idioma: Inglês
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