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A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Lopes, M W ; Leal, R B ; Guarnieri, R ; Schwarzbold, M L ; Hoeller, A ; Diaz, A P ; Boos, G L ; Lin, K ; Linhares, M N ; Nunes, J C ; Quevedo, J ; Bortolotto, Z A ; Markowitsch, H J ; Lightman, S L ; Walz, R

Translational psychiatry, 2016-12, Vol.6 (12), p.e986-e986 [Revista revisada por pares]

United States: Nature Publishing Group

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A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system
Autor: Lopes, M W ; Leal, R B ; Guarnieri, R ; Schwarzbold, M L ; Hoeller, A ; Diaz, A P ; Boos, G L ; Lin, K ; Linhares, M N ; Nunes, J C ; Quevedo, J ; Bortolotto, Z A ; Markowitsch, H J ; Lightman, S L ; Walz, R
Materias: Adult ; Amygdala - drug effects ; Anti-Inflammatory Agents - pharmacology ; Dexamethasone - pharmacology ; Epilepsy, Temporal Lobe - surgery ; Female ; Hippocampus - drug effects ; Hippocampus - surgery ; Humans ; Limbic System - drug effects ; Male ; Neuronal Plasticity - drug effects ; Original ; Phosphorylation - drug effects ; Receptors, AMPA - metabolism ; Signal Transduction - drug effects ; Temporal Lobe - drug effects ; Temporal Lobe - surgery
Es parte de: Translational psychiatry, 2016-12, Vol.6 (12), p.e986-e986
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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These authors contributed equally to this work.
Descripción: Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment has been paralleled by the high incidence of acute and chronic neuropsychiatric side effects, which reinforces the brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation (long-term potentiation, LTP) or depotentiation (long-term depression, LTD) of synaptic transmission efficacy, and the phosphorylation state of Ser831 and Ser845 sites, in the GluA1 subunit of the glutamate AMPA receptors, are a critical event for these synaptic neuroplasticity events. Through a quasi-randomized controlled study, we show that a single high dexamethasone dose significantly reduces in a dose-dependent manner the levels of GluA1-Ser831 phosphorylation in the amygdala resected during surgery for temporal lobe epilepsy. This is the first report demonstrating GC effects on key markers of synaptic neuroplasticity in the human limbic system. The results contribute to understanding how GC affects the human brain under physiologic and pharmacologic conditions.
Editor: United States: Nature Publishing Group
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A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Lopes, M W ; Leal, R B ; Guarnieri, R ; Schwarzbold, M L ; Hoeller, A ; Diaz, A P ; Boos, G L ; Lin, K ; Linhares, M N ; Nunes, J C ; Quevedo, J ; Bortolotto, Z A ; Markowitsch, H J ; Lightman, S L ; Walz, R

United States: Nature Publishing Group

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