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Interacting TCP and NLP transcription factors control plant responses to nitrate availability

Guan, Peizhu ; Ripoll, Juan-José ; Wang, Renhou ; Vuong, Lam ; Bailey-Steinitz, Lindsay J. ; Ye, Dening ; Crawford, Nigel M.

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (9), p.2419-2424 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Interacting TCP and NLP transcription factors control plant responses to nitrate availability
Autor: Guan, Peizhu ; Ripoll, Juan-José ; Wang, Renhou ; Vuong, Lam ; Bailey-Steinitz, Lindsay J. ; Ye, Dening ; Crawford, Nigel M.
Assuntos: Amino Acid Sequence ; Arabidopsis - drug effects ; Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Binding Sites ; Biological Sciences ; Cell cycle ; Cyclin B - genetics ; Cyclin B - metabolism ; Cycloidea ; Flowers & plants ; G2 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Plant ; Genes ; Nitrate Reductase - genetics ; Nitrate Reductase - metabolism ; Nitrates - metabolism ; Nitrates - pharmacology ; Nitrogen ; Plant biology ; Plant Roots - drug effects ; Plant Roots - genetics ; Plant Roots - growth & development ; Plant Roots - metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; Proteins ; Sequence Alignment ; Sequence Homology, Amino Acid ; Signal Transduction ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (9), p.2419-2424
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: P.G. and N.M.C. designed research; P.G., J.-J.R., L.V., and L.J.B.-S. performed research; J.-J.R. and R.W. contributed new reagents/analytic tools; P.G. and D.Y. analyzed data; and P.G. and N.M.C. wrote the paper.
1Present address: The Climate Corporation, St. Louis, MO 63141.
Edited by Joseph R. Ecker, Howard Hughes Medical Institute–The Salk Institute for Biological Studies, La Jolla, CA, and approved January 17, 2017 (received for review September 20, 2016)
Descrição: Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestrate nitrogen (N) responses and cell-cycle regulation. Here we report that teosinte branched1/cycloidea/proliferating cell factor1-20 (TCP20) and NIN-like protein (NLP) transcription factors NLP6 and NLP7, which act as activators of nitrate assimilatory genes, bind to adjacent sites in the upstream promoter region of the nitrate reductase gene, NIA1, and physically interact under continuous nitrate and N-starvation conditions. Regions of these proteins necessary for these interactions were found to include the type I/II Phox and Bem1p (PB1) domains of NLP6&7, a protein-interaction module conserved in animals for nutrient signaling, and the histidine- and glutamine-rich domain of TCP20, which is conserved across plant species. Under N starvation, TCP20-NLP6&7 heterodimers accumulate in the nucleus, and this coincides with TCP20 and NLP6&7-dependent up-regulation of nitrate assimilation and signaling genes and down-regulation of the G₂/M cell-cycle marker gene, CYCB1;1. TCP20 and NLP6&7 also support root meristem growth under N starvation. These findings provide insights into how plants coordinate responses to nitrate availability, linking nitrate assimilation and signaling with cell-cycle progression.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Interacting TCP and NLP transcription factors control plant responses to nitrate availability

Guan, Peizhu ; Ripoll, Juan-José ; Wang, Renhou ; Vuong, Lam ; Bailey-Steinitz, Lindsay J. ; Ye, Dening ; Crawford, Nigel M.

United States: National Academy of Sciences

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