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Membrane tension controls adhesion positioning at the leading edge of cells

Pontes, Bruno ; Monzo, Pascale ; Gole, Laurent ; Le Roux, Anabel-Lise ; Kosmalska, Anita Joanna ; Tam, Zhi Yang ; Luo, Weiwei ; Kan, Sophie ; Viasnoff, Virgile ; Roca-Cusachs, Pere ; Tucker-Kellogg, Lisa ; Gauthier, Nils C

The Journal of cell biology, 2017-09, Vol.216 (9), p.2959-2977 [Periódico revisado por pares]

United States: Rockefeller University Press

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Título:
Membrane tension controls adhesion positioning at the leading edge of cells
Autor: Pontes, Bruno ; Monzo, Pascale ; Gole, Laurent ; Le Roux, Anabel-Lise ; Kosmalska, Anita Joanna ; Tam, Zhi Yang ; Luo, Weiwei ; Kan, Sophie ; Viasnoff, Virgile ; Roca-Cusachs, Pere ; Tucker-Kellogg, Lisa ; Gauthier, Nils C
Assuntos: Actin ; Actins - genetics ; Actins - metabolism ; Adhesion ; Animal physiology ; Animals ; Cell Adhesion ; Cell adhesion & migration ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Cell Membrane - metabolism ; Cell Membrane - physiology ; Cell membranes ; Cell migration ; Cell motility ; Cell Movement ; Cell Shape ; Cells, Cultured ; Computer Simulation ; Cytoskeletal proteins ; Cytoskeleton ; Cytoskeleton - metabolism ; Cytoskeleton - physiology ; Fasteners ; Fibroblasts - metabolism ; Fibroblasts - physiology ; Fisiologia animal ; Genetics ; Genètica ; Mechanotransduction ; Mechanotransduction, Cellular ; Membranes ; Membranes cel·lulars ; Mice ; Microfilament Proteins - genetics ; Microfilament Proteins - metabolism ; Microscopy, Fluorescence ; Microscopy, Video ; Migració cel·lular ; Models, Biological ; Motilitat cel·lular ; Myosin ; Myosin Type II - metabolism ; Phosphoproteins - genetics ; Phosphoproteins - metabolism ; Plasma ; Proteins ; Proteïnes citosquelètiques ; Pseudopodia - metabolism ; Pseudopodia - physiology ; Stress, Mechanical ; Tension ; Time Factors ; Transfection ; Vinculin ; Vinculin - metabolism
É parte de: The Journal of cell biology, 2017-09, Vol.216 (9), p.2959-2977
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
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Descrição: Cell migration is dependent on adhesion dynamics and actin cytoskeleton remodeling at the leading edge. These events may be physically constrained by the plasma membrane. Here, we show that the mechanical signal produced by an increase in plasma membrane tension triggers the positioning of new rows of adhesions at the leading edge. During protrusion, as membrane tension increases, velocity slows, and the lamellipodium buckles upward in a myosin II-independent manner. The buckling occurs between the front of the lamellipodium, where nascent adhesions are positioned in rows, and the base of the lamellipodium, where a vinculin-dependent clutch couples actin to previously positioned adhesions. As membrane tension decreases, protrusion resumes and buckling disappears, until the next cycle. We propose that the mechanical signal of membrane tension exerts upstream control in mechanotransduction by periodically compressing and relaxing the lamellipodium, leading to the positioning of adhesions at the leading edge of cells.
Editor: United States: Rockefeller University Press
Idioma: Inglês

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Membrane tension controls adhesion positioning at the leading edge of cells

Pontes, Bruno ; Monzo, Pascale ; Gole, Laurent ; Le Roux, Anabel-Lise ; Kosmalska, Anita Joanna ; Tam, Zhi Yang ; Luo, Weiwei ; Kan, Sophie ; Viasnoff, Virgile ; Roca-Cusachs, Pere ; Tucker-Kellogg, Lisa ; Gauthier, Nils C

United States: Rockefeller University Press

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