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Mutagenicity, cytotoxic and antioxidant activities of Ricinus communis different parts

Abbas, Mazhar ; Ali, Abid ; Arshad, Muhammad ; Atta, Asia ; Mehmood, Zahed ; Tahir, Imtiaz Mahmood ; Iqbal, Munawar

Chemistry Central journal, 2018-01, Vol.12 (1), p.3, Article 3

Cham: Springer International Publishing

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  • Título:
    Mutagenicity, cytotoxic and antioxidant activities of Ricinus communis different parts
  • Autor: Abbas, Mazhar ; Ali, Abid ; Arshad, Muhammad ; Atta, Asia ; Mehmood, Zahed ; Tahir, Imtiaz Mahmood ; Iqbal, Munawar
  • Materias: Biological Chemistry ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Research Article
  • Es parte de: Chemistry Central journal, 2018-01, Vol.12 (1), p.3, Article 3
  • Descripción: Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. communis along with antioxidant and antimicrobial activities. Cytotoxicity was evaluated by hemolytic and brine shrimp assays, whereas Ames test (TA98 and TA100) was used for mutagenicity evaluation. Plant different parts were extracted in methanol by shaking, sonication and Soxhlet extraction methods. The R. communis methanolic extracts showed promising antioxidant activity evaluated as through total phenolic contents (TPC), total flavonoid content (TFC), DPPH free radical inhibition, reducing power and inhibition of linoleic acid oxidation. R. communis seeds, stem, leaves, fruit and root methanolic extracts showed mild to moderate cytotoxicity against red blood cells (RBCs) of human and bovine. Brine shrimp lethality also revealed the cytotoxic nature of extracts with LC 50 in the range of 0.22–3.70 (µg/mL) (shaking), 1.59–60.92 (µg/mL) (sonication) and 0.72–33.60 (µg/mL) (Soxhlet), whereas LC 90 values were in the range of 345.42–1695.81, 660.50–14,794.40 and 641.62–15,047.80 µg/mL for shaking, sonication and Soxhlet extraction methods, respectively. R. communis methanolic extracts revealed mild mutagenicity against TA98 (range 1975 ± 67 to 2628 ± 79 revertant colonies) and TA100 (range 2773 ± 92 to 3461 ± 147 revertant colonies) strains and these values were 3267 ± 278 and 4720 ± 346 revertant colonies in case of TA98 and TA100 positive controls, respectively. R. communis methanolic extracts prevented the H 2 O 2 and UV to Plasmid pBR 322 DNA oxidative damage. Results revealed that R. communis is a potential source of bioactive compounds and in future studies the bioactive compounds will be identified by advanced spectroscopic techniques.
  • Editor: Cham: Springer International Publishing
  • Idioma: Inglés
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