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Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress

Delgado, María Graciela ; Oliva, Carlos ; López, Estefanía ; Ibacache, Andrés ; Galaz, Alex ; Delgado, Ricardo ; Barros, L Felipe ; Sierralta, Jimena

Scientific reports, 2018-01, Vol.8 (1), p.1186-13, Article 1186 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress
Autor: Delgado, María Graciela ; Oliva, Carlos ; López, Estefanía ; Ibacache, Andrés ; Galaz, Alex ; Delgado, Ricardo ; Barros, L Felipe ; Sierralta, Jimena
Assuntos: Amino Acid Sequence ; Animals ; Cell culture ; Cell Line ; Cell Survival ; Central nervous system ; Chromosome Pairing ; Drosophila ; Fluorescence resonance energy transfer ; Humans ; Insects ; Lactic acid ; Locomotion ; Membrane Transport Proteins - chemistry ; Membrane Transport Proteins - genetics ; Membrane Transport Proteins - metabolism ; Monocarboxylic Acid Transporters - chemistry ; Monocarboxylic Acid Transporters - genetics ; Monocarboxylic Acid Transporters - metabolism ; Neuroglia - metabolism ; Neuronal-glial interactions ; Neurons - metabolism ; Nutrient deficiency ; Protein transport ; Pyruvic acid ; Stress, Physiological ; Synaptic transmission
É parte de: Scientific reports, 2018-01, Vol.8 (1), p.1186-13, Article 1186
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SourceType-Scholarly Journals-1
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Descrição: The intercellular transport of lactate is crucial for the astrocyte-to-neuron lactate shuttle (ANLS), a model of brain energetics according to which neurons are fueled by astrocytic lactate. In this study we show that the Drosophila chaski gene encodes a monocarboxylate transporter protein (MCT/SLC16A) which functions as a lactate/pyruvate transporter, as demonstrated by heterologous expression in mammalian cell culture using a genetically encoded FRET nanosensor. chaski expression is prominent in the Drosophila central nervous system and it is particularly enriched in glia over neurons. chaski mutants exhibit defects in a high energy demanding process such as synaptic transmission, as well as in locomotion and survival under nutritional stress. Remarkably, locomotion and survival under nutritional stress defects are restored by chaski expression in glia cells. Our findings are consistent with a major role for intercellular lactate shuttling in the brain metabolism of Drosophila.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress

Delgado, María Graciela ; Oliva, Carlos ; López, Estefanía ; Ibacache, Andrés ; Galaz, Alex ; Delgado, Ricardo ; Barros, L Felipe ; Sierralta, Jimena

England: Nature Publishing Group

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