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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats

Reis, Natany Garcia ; Francescato, Heloísa Della Coletta ; de Almeida, Lucas Ferreira ; Silva, Cleonice Giovanini Alves da ; Costa, Roberto Silva ; Coimbra, Terezila Machado

Scientific reports, 2019-05, Vol.9 (1), p.7090, Article 7090 [Periódico revisado por pares]

England: Nature Publishing Group

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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats
Autor: Reis, Natany Garcia ; Francescato, Heloísa Della Coletta ; de Almeida, Lucas Ferreira ; Silva, Cleonice Giovanini Alves da ; Costa, Roberto Silva ; Coimbra, Terezila Machado
Assuntos: Acute Kidney Injury - blood ; Acute Kidney Injury - drug therapy ; Acute Kidney Injury - etiology ; Acute Kidney Injury - urine ; Animals ; Apoptosis ; Apoptosis - drug effects ; Calcitriol ; Calcitriol - pharmacology ; Calcitriol - therapeutic use ; Calcium - blood ; Creatine Kinase - blood ; Excretion ; Glomerular Filtration Rate - drug effects ; Glycerol ; Glycerol - pharmacology ; Inflammation ; Inflammation - drug therapy ; Injection ; Kidney Function Tests ; Kidneys ; Male ; Oxidative stress ; Oxidative Stress - drug effects ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Rats ; Rats, Wistar ; Renal cortex ; Renal function ; Rhabdomyolysis ; Rhabdomyolysis - chemically induced ; Rhabdomyolysis - complications ; Sodium chloride ; Structure-function relationships ; Urine ; Vitamin D ; Vitamin D-binding protein ; Vitamin D-Binding Protein - urine
É parte de: Scientific reports, 2019-05, Vol.9 (1), p.7090, Article 7090
Descrição: Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular muscle content to the extracellular compartment and acute kidney injury (AKI). Oxidative stress and the inflammatory processes contribute to the disturbances in renal function and structure observed in this model. This study evaluated the effect of calcitriol administration in AKI induced by rhabdomyolysis and its relationship with oxidative damage and inflammatory process. Male Wistar Hannover rats were treated with calcitriol (6 ng/day) or vehicle (0.9% NaCl) for 7 days and were injected with 50% glycerol or saline 3 days after the beginning of calcitriol or saline administration. Four days after glycerol or saline injection, urine, plasma and renal tissue samples were collected for renal function and structural analysis. The oxidative stress and the inflammatory processes were also evaluated. Glycerol-injected rats presented increased sodium fractional excretion and decreased glomerular filtration rates. These alterations were associated with tubular injury in the renal cortex. These animals also presented increased oxidative damage, apoptosis, inflammation, higher urinary excretion of vitamin D-binding protein and decreased cubilin expression in renal tissue. All these alterations were less intense in calcitriol-treated animals. This effect was associated with decreases in oxidative damage and inflammation.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats

Reis, Natany Garcia ; Francescato, Heloísa Della Coletta ; de Almeida, Lucas Ferreira ; Silva, Cleonice Giovanini Alves da ; Costa, Roberto Silva ; Coimbra, Terezila Machado

England: Nature Publishing Group

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